Anti-Orai2 Antibody ACC-061 from Alomone Labs, Ltd.

Product Specs
ItemAnti-Orai2 Antibody
CompanyAlomone Labs, Ltd.
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberACC-061
Brand/TrademarkAlomone Labs Ltd
NCBI Gene AliasesA730041O15Rik, Tmem142b
Conjugate/TagUnconjugated
HostRabbit
ApplicationsIF, IHC, WB
FormatReconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3., Lyophilized Powder
Quantity1 X 50 mcl, 1 X 0.2 ml, 1 X 25 mcl
ClonalityPolyclonal
ReactivityHuman (Tested);Mouse (Tested);Rat (Tested)
Antibody TypePrimary
Concentration08 mg/ml
PurityAffinity purified on immobilized antigen
IsotypeIgG
ImmunogenSynthetic peptide
Domain/Region/TerminusIntracellular, N-terminus
Research AreaBreast cancer, Cancer, Microglia, Astrocytes, T-cells, t cells, t lymphocytes, immunology, immunity, immune cells
Gene NameORAI2
TargetOrai2 Channel
ValidationAs per applications, See images, contact for clarifications
NCBI Full Gene NameORAI calcium release-activated calcium modulator 2
pH RangepH 7.4

Specifications/Features

starting price for North American orders, for exact pricing view product page

Sequence

CPEPGHKGMDYRDWVRR, corresponding to amino acid residues 16-32 of mouse Orai2

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Alomone Labs, Ltd.

PO Box 4287

Jerusalem 91042

Israel

Phone: +972-2-587-2202
+972-2-587-1101

Company Profile

Website: http://www.alomone.com/

(1) Orai1 is an Entotic Ca(2+) Channel for Non-Apoptotic Cell Death, Entosis in Cancer DevelopmentAdvanced science (Weinheim, Baden-Wurttemberg, Germany)May 1, 2023Lee AR, Park CY.Scientific). Antibodies and Protein Detection Orai1 (Santa Cruz Biotechnology, SC‐377281), Orai2 (Alomone, ACC‐061), Orai3 (Alomone, ACC‐065), STIM1 (Abnova, H00006786‐M01), STIM2 (Cell Signaling Technology, 4917S),

(2) Insulin-activated store-operated Ca²⁺ entry via Orai1 induces podocyte actin remodeling and causes proteinuriaNature communicationsNovember 11, 2021Kim JH, Hwang KH, Dang BTN, Eom M, Kong ID, Gwack Y, Yu S, Gee HY, Birnbaumer L, Park KS, et al.dilution, sc21537) were purchased from Santa Cruz Biotechnology. Antibodies against Orai2 (1:1000 dilution, ACC-061), Orai3 (1:1000 dilution, ACC-065), STIM2 (1:100 dilution, ACC-064), and TRPC6 (1:500 dilution, ACC-120)

(3) Inhibition of Orai Channel Function Regulates Mas-Related G Protein-Coupled Receptor-Mediated Responses in Mast CellsFrontiers in immunologyJanuary 1, 2021Chaki S, Alkanfari I, Roy S, Amponnawarat A, Hui Y, Oskeritzian CA, Ali H.

(4) Store-Operated Calcium Channels Are Involved in Spontaneous Slow Calcium Oscillations in Striatal NeuronsFrontiers in cellular neuroscienceJanuary 1, 2019Kikuta S, Iguchi Y, Kakizaki T, Kobayashi K, Yanagawa Y, Takada M, Osanai M.

(5) Hypoxia selectively upregulates cation channels and increases cytosolic [Ca²⁺] in pulmonary, but not coronary, arterial smooth muscle cellsAmerican journal of physiology. Cell physiologyApril 1, 2018He X, Song S, Ayon RJ, Balisterieri A, Black SM, Makino A, Wier WG, Zang WJ, Yuan JX.1:1,000; catalog no. ACC-060, Alomone, Jerusalem, Israel) (18, 69), Orai2 (diluted 1:1,000; catalog no. ACC-061, Alomone) (18), and TRPC6 (diluted 1:1,000; catalog no. ACC-120, Alomone) (27). The membranes were then incubated

(6) Expression of calcium release-activated and voltage-gated calcium channels genes in peripheral blood mononuclear cells is altered in pregnancy and in type 1 diabetesPloS oneJanuary 1, 2018Bhandage AK, Jin Z, Korol SV, Tafreshiha AS, Gohel P, Hellgren C, Espes D, Carlsson PO, Sundström-Poromaa I, Birnir B.Cell Signaling Technology, Cat No. 4917), ORAI1 (1:500, Alomone labs, Cat No. ACC-060), ORAI2 (1:500, Alomone labs, Cat No. ACC-061), CaV1.3 (1:500, Alomone labs, Cat No. ACC-005), CaV2.3 (1:500, Alomone labs, Cat No. ACC-006) and GAPDH

(7) ORAI channels are critical for receptor-mediated endocytosis of albuminNature communicationsDecember 4, 2017Zeng B, Chen GL, Garcia-Vaz E, Bhandari S, Daskoulidou N, Berglund LM, Jiang H, Hallett T, Zhou LP, Huang L, et al.nitrocellulose membrane46. The blot was then incubated with polyclonal anti-ORAI1 (ACC-060), anti-ORAI2 (ACC-061) or anti-STIM1 (ACC-063) at 1:500 dilution (Alomone Labs, Jerusalem, Israel), and anti-ORAI3 (#4117)

(8) DPB162-AE, an inhibitor of store-operated Ca²⁺ entry, can deplete the endoplasmic reticulum Ca²⁺ storeCell calciumMarch 1, 2017Bittremieux M, Gerasimenko JV, Schuermans M, Luyten T, Stapleton E, Alzayady KJ, De Smedt H, Yule DI, Mikoshiba K, Vangheluwe P, et al.

(9) Store-Operated Calcium Entry Is Required for mGluR-Dependent Long Term Depression in Cortical NeuronsFrontiers in cellular neuroscienceJanuary 1, 2017González-Sánchez P, Del Arco A, Esteban JA, Satrústegui J.

(10) Notch Activation of Ca(2+) Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary HypertensionAmerican journal of respiratory cell and molecular biologySeptember 1, 2015Smith KA, Voiriot G, Tang H, Fraidenburg DR, Song S, Yamamura H, Yamamura A, Guo Q, Wan J, Pohl NM, et al.(PRS3897; Sigma-Aldrich), RBP-Jk (sc-28713; Santa Cruz), Orai1 (ACC-060; Alomone Labs, Jerusalem, Israel), Orai2 (ACC-061; Alomone Labs), STIM2 (S8572; SigmaAldrich), Jag-1 (2620; Cell Signaling Technologies, Beverly, MA),

(11) Orai/CRACM1 and KCa3.1 ion channels interact in the human lung mast cell plasma membraneCell communication and signaling : CCSJuly 16, 2015Duffy SM, Ashmole I, Smallwood DT, Leyland ML, Bradding P.

(12) Orai1-Orai2 complex is involved in store-operated calcium entry in chondrocyte cell linesCell calciumMay 1, 2015Inayama M, Suzuki Y, Yamada S, Kurita T, Yamamura H, Ohya S, Giles WR, Imaizumi Y.

(13) Upregulated expression of STIM2, TRPC6, and Orai2 contributes to the transition of pulmonary arterial smooth muscle cells from a contractile to proliferative phenotypeAmerican journal of physiology. Cell physiologyApril 15, 2015Fernandez RA, Wan J, Song S, Smith KA, Gu Y, Tauseef M, Tang H, Makino A, Mehta D, Yuan JX.

(14) STIM1 is necessary for store-operated calcium entry in turning growth conesJournal of neurochemistrySeptember 1, 2012Mitchell CB, Gasperini RJ, Small DH, Foa L.

(15) SERCA2a controls the mode of agonist-induced intracellular Ca2+ signal, transcription factor NFAT and proliferation in human vascular smooth muscle cellsJournal of molecular and cellular cardiologyApril 1, 2011Bobe R, Hadri L, Lopez JJ, Sassi Y, Atassi F, Karakikes I, Liang L, Limon I, Lompré AM, Hatem SN, et al.BD Biosciences), anti-PP2B (calcineurin, 556350, BD Biosciences), anti-STIM1 (ACC-63, Alomone labs), anti-Orai2 (ACC-061, Alomone labs), anti-ORAI1 (ACC-60, Alomone lab), anti-ORAI1 (sc-68895), anti-Cav1.2 calcium channel

(16) Store-operated Ca²+ signaling in dendritic cells occurs independently of STIM1Journal of leukocyte biologyJanuary 1, 2011Bandyopadhyay BC, Pingle SC, Ahern GP.

(17) The role of caveolae and caveolin 1 in calcium handling in pacing and contraction of mouse intestineJournal of cellular and molecular medicineFebruary 1, 2009Daniel EE, Eteraf T, Sommer B, Cho WJ, Elyazbi A.IgG (Cat. No. 160406, BD Transduction Labs; San Jose, CA, USA) and rabbit anti-Orai-2 IgG (Cat. No. ACC-061, Alomone Labs; Jerusalem, Israel) were used as primary antibodies. The 5-μm cryosections were pre-incubated

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Anti-Orai2 Antibody from Alomone Labs, Ltd.

Description

Specifications/Features

Sequence

Alomone Labs, Ltd.

Citations (17)

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Anti-Orai2 Antibody from Alomone Labs, Ltd.

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