Anti-MLKL antibody GTX107538 from GeneTex

Product Specs
ItemAnti-MLKL antibody
CompanyGeneTex
Price $169.00Supplier Page
Catalog NumberGTX107538
Quantity25 µl
ApplicationsWB, IP
Conjugate/TagUnconjugated
ClonalityPolyclonal
FormatPBS, 20% Glycerol, 0.025% ProClin 300
ReactivityHuman
HostRabbit
ImmunogenRecombinant protein encompassing a sequence within the center region of human MLKL. The exact sequence is proprietary
Concentration0.52mg/ml
IsotypeIgG
Antibody TypePrimary Antibodies
NCBI Full Gene Namemixed lineage kinase domain like pseudokinase
NCBI Gene Aliasesmixed lineage kinase domain like pseudokinase, hMLKL, hMLKL
PurityPurified by antigen-affinity chromatography
TargetMLKL
Research AreaCell Biology
Gene NameMLKL
Molecular Weight54

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GeneTex

GeneTex, Inc. 2456 Alton Parkway

Irvine, California 92606

United States

Phone: 1-877-GeneTex (436-3839) or 949-553-1900
Fax: 949-309-2888

Company Profile

Website: http://www.genetex.com

(1) Casein kinase I isoforms contribute to platelet activation and thrombogenesis via RIPK3–MLKL signalingCommunications BiologySeptember 30, 2025Vipin Singh, Mohammad Ekhlak, Susheel N. Chaurasia, Debabrata Dashantibody and anti-phospho (Ser-358)-MLKL (p-MLKL) monoclonal antibody were the products of GeneTex (#GTX107538) and Abcam (#ab187091), respectively. Monoclonal antibodies against phospho-RIPK3 (Ser-227) (#93654),

(2) Opposing regulation of the K63-linked polyubiquitination of RIPK3 by SMURF1 and USP5 in necroptosisNature communicationsAugust 9, 2025Hwang CH, Lee M, Kim JW, Nam YW, Hwang G, Ryu HS, Seo J, Lee EW, Ko HW, Song J.immunoblot analysis: RIPK1 (#610459; BD Biosciences), RIPK3 (#13526; Cell Signaling Technology), MLKL (#GTX107538; GeneTex), phospho-RIPK1 Ser166 (#65746; Cell Signaling), phospho-RIPK3 Ser227 (#ab209384; Abcam), phospho-MLKL

(3) Optogenetically Activatable MLKL as a Standalone Functional Module for Necroptosis and Therapeutic Applications in Antitumoral ImmunityAdvanced science (Weinheim, Baden-Wurttemberg, Germany)April 1, 2025Jeong DH, Kim S, Park HH, Woo KJ, Choi JI, Choi M, Shin J, Park SH, Seon MW, Lee D, et al.anti‐p‐RIPK3 (S227) (Abcam #ab209384, 1:1000), anti‐MLKL (Abcam #184718, 1:1000), anti‐MLKL (Genetex #GTX107538, 1:1000), anti‐p‐MLKL (Abcam #ab187091, 1:1000), anti‐p‐TRIM28 (S473) (BioLegend #654102, 1:2000), anti‐HMGB1

(4) EGFR inhibits TNF-α-mediated pathway by phosphorylating TNFR1 at tyrosine 360 and 401Cell death and differentiationOctober 1, 2024Nam YW, Shin JH, Kim S, Hwang CH, Lee CS, Hwang G, Kim HR, Roe JS, Song J.anti-RIPK3 (Cell signalling, #13526), anti-phospho-RIPK3 (Ser27) (Abcam, ab209384), anti-MLKL (Genetex, GTX107538), anti-phospho-MLKL (Ser358) (Cell signalling, 91689S), anti-caspase-8 (Cell signalling, #9746), anti-PARP

(5) Targeting P2Y(14)R protects against necroptosis of intestinal epithelial cells through PKA/CREB/RIPK1 axis in ulcerative colitisNature communicationsMarch 7, 2024Liu C, Wang H, Han L, Zhu Y, Ni S, Zhi J, Yang X, Zhi J, Sheng T, Li H, et al.using 5% milk in TBST, probed with primary antibody, RIPK1 (17519-1-AP, Proteintech, 1:1000), MLKL (GTX107538-100, GeneTex, 1:1000), RIPK3 (17563-1-AP, Proteintech, 1:1000), p-MLKL (EPR9514, Abcam, 1:1000), PKA

(6) MLKL polymerization-induced lysosomal membrane permeabilization promotes necroptosisCell death and differentiationJanuary 1, 2024Liu S, Perez P, Sun X, Chen K, Fatirkhorani R, Mammadova J, Wang Z.(#14031), anti-Calreticulin (#2891) and anti-Tubulin (#2146). Other antibodies include, anti-MLKL (GTX107538, GeneTex), anti-RIPK1 (610459, BD), anti-Flag M2-HRP (A8592, Sigma), anti-LAMP2 (abcam, ab25631) and

(7) Skp2-mediated MLKL degradation confers cisplatin-resistant in non-small cell lung cancer cellsCommunications biologyAugust 2, 2023Zhou H, Zhou L, Guan Q, Hou X, Wang C, Liu L, Wang J, Yu X, Li W, Liu H.Antibody against GFP tag (TA150032, 1:1000) was purchased from OriGene (Rockville, MD). MLKL antibody (#GTX107538, 1:1000) was from GeneTex (Irvine, CA). MLKL antibody (#orb32399, 1:1000) was from Biorbyt (St. Louis,

(8) Necroptosis executioner MLKL plays pivotal roles in agonist-induced platelet prothrombotic responses and lytic cell death in a temporal orderCell death and differentiationAugust 1, 2023Ekhlak M, Kulkarni PP, Singh V, Chaurasia SN, Mohapatra SK, Chaurasia RN, Dash D.

(9) Cell Death Triggers Induce MLKL Cleavage in Multiple Myeloma Cells, Which may Promote Cell DeathFrontiers in oncologyJanuary 1, 2022Chen J, Wang S, Blokhuis B, Ruijtenbeek R, Garssen J, Redegeld F.Cell Signaling Technology; anti-GAPDH (sc-47724) was obtained from Santa Cruz Biotechnology. Anti-MLKL antibody (GTX107538) for immunoprecipitation was obtained from GeneTex (Hsinchu, Taiwan). Horse radish peroxidase-conjugated

(10) Evolutionary Profile for (Host and Viral) MLKL Indicates Its Activities as a Battlefront for Extensive CounteradaptationMolecular biology and evolutionDecember 9, 2021Palmer SN, Chappidi S, Pinkham C, Hancks DC.primary antibodies at 4 °C overnight. The following primary antibodies were used: human MLKL (GeneTex, GTX107538), mouse MLKL (Cell Signaling Technology, 37705S), STAT1 D1K9Y Rabbit mAb (Cell Signaling Technology,

(11) RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1γ promote apoptosis and necroptosisNature communicationsDecember 3, 2021Du J, Xiang Y, Liu H, Liu S, Kumar A, Xing C, Wang Z.Xiaodong Wang, 1:5000), anti-phospho-S227 of RIPK3 (Abcam, ab209384, 1:1000), anti-human MLKL (GeneTex, GTX107538, 1:1000), anti-mouse MLKL (Aviva Systems Biology, OAAB10571, 1:1000), anti-phospho-S358 of MLKL (Abcam,

(12) Quantitative analysis of phosphoproteome in necroptosis reveals a role of TRIM28 phosphorylation in promoting necroptosis-induced cytokine productionCell death & diseaseOctober 23, 2021Zu R, Yu Z, Zhao J, Lu X, Liang W, Sun L, Si C, Zhu K, Zhang T, Li G, et al.analysis: RIPK1 (Homemade), phospho-RIPK1 (S166) (CST, 65746), MLKL (Homemade; Abcam, ab183770; GeneTex, GTX107538), phospho-MLKL (T357/S358) (Abcam, ab187091), TRIM28 (Abcam, ab22553; CST, 4123), phospho-TRIM28 (S473)

(13) Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injuryNature communicationsJuly 20, 2021Tonnus W, Meyer C, Steinebach C, Belavgeni A, von Mässenhausen A, Gonzalez NZ, Maremonti F, Gembardt F, Himmerkus N, Latk M, et al.Cat# 65746, 1:1000 dilution), anti-pS358-MLKL, (Abcam, ab187091, 1:1000 dilution), anti-MLKL (Genetex, GTX107538, 1:1000 dilution) and anti-β-Actin (Cell Signaling, Cat# 3700S, 1:1000 dilution). Secondary antibodies

(14) Beclin 1 functions as a negative modulator of MLKL oligomerisation by integrating into the necrosome complexCell death and differentiationNovember 1, 2020Seo J, Seong D, Nam YW, Hwang CH, Lee SR, Lee CS, Jin Y, Lee HW, Oh DB, Vandenabeele P, et al.Novus Biologicals, Centennial, Co, USA), p-hRIPK3 (S227) (1:2000; ab209384; Abcam), hMLKL (1:2000; GTX107538; GeneTex, Irvine, CA, USA), mMLKL (1:2000; AP14272b; Abgent, San Diego, CA, USA), p-hMLKL (S358) (1:2000;

(15) A necroptotic-independent function of MLKL in regulating endothelial cell adhesion molecule expressionCell death & diseaseApril 24, 2020Dai J, Zhang C, Guo L, He H, Jiang K, Huang Y, Zhang X, Zhang H, Wei W, Zhang Y, et al.radioimmunoprecipitation assay (RIPA) buffer. Cell lysates were then incubated with rabbit anti-MLKL (GeneTex, GTX107538) and anti-rabbit Dynabeads (Invitrogen, 00695229) overnight at 4 °C. The immunoprecipitated proteins

(16) CK1δ as a potential therapeutic target to treat bladder cancerAgingApril 13, 2020Lin YC, Chen MC, Hsieh TH, Liou JP, Chen CH.

(17) Necroptosis-blocking compound NBC1 targets heat shock protein 70 to inhibit MLKL polymerization and necroptosisProceedings of the National Academy of Sciences of the United States of AmericaMarch 24, 2020Johnston AN, Ma Y, Liu H, Liu S, Hanna-Addams S, Chen S, Chen C, Wang Z.PES-Cl (Millipore), VER155008, anti-FLAG M2 antibody and affinity gel (Sigma), anti-human MLKL (GeneTex, GTX107538), anti–phospho-S358 of MLKL (Abcam, ab187091), antiRIPK1 (BD, no. 551042), anti-lactate dehydrogenase

(18) CK1α, CK1δ, and CK1ε are necrosome components which phosphorylate serine 227 of human RIPK3 to activate necroptosisProceedings of the National Academy of Sciences of the United States of AmericaJanuary 28, 2020Hanna-Addams S, Liu S, Liu H, Chen S, Wang Z.anti-myc and affinity gel (Sigma), anti-phospho-S227 of RIPK3 (Abcam, ab209384), anti-human MLKL (GeneTex, GTX107538), anti-phospho-S358 of MLKL (Abcam, ab187091), anti-RIPK1 (BD, 551042), anti-phospho-S166 of RIPK1 (Cell Signaling

(19) RIP1, RIP3, and MLKL Contribute to Cell Death Caused by Clostridium perfringens EnterotoxinmBioDecember 17, 2019Shrestha A, Mehdizadeh Gohari I, McClane BA.,Cell Signaling Technology,13526S MLKL (D216N) rabbit MAb*,Cell Signaling Technology,14993S MLKL rabbit polyclonal*,GeneTex,GTX107538 Sources and properties of antibodies used in this study a*, Validated by supplier against appropriate

(20) Upregulation of human glycolipid transfer protein (GLTP) induces necroptosis in colon carcinoma cellsBiochimica et biophysica acta. Molecular and cell biology of lipidsFebruary 1, 2019Mishra SK, Stephenson DJ, Chalfant CE, Brown RE.9542), cleaved PARP-Asp214 (Cell Signaling Tech., 9541), p-MLKL (ab187091; Abcam), MLKL (GeneTex Inc. GTX107538), RIPK-3 (Cell Signaling Tech., 95702), Tubulin (Cell Signaling Tech., 86298). Immunoreactive bands

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Anti-MLKL antibody

Anti-MLKL antibody

Anti-MLKL antibody

Anti-MLKL antibody

Anti-MLKL antibody from GeneTex

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Anti-MLKL antibody from GeneTex

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