EEA1 (G-4) Antibody sc-137130 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemEEA1 (G-4) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-137130
NCBI Gene AliasesZFYVE2, B230358H09Rik, A430109M19Rik, MST105, MSTP105
Antibody TypePrimary Antibodies
Quantity200 µg/ml
CloneG-4
FormatPurified
Reactivitymouse, rat, human, monkey
Conjugate/TagUnconjugated
ClonalityMonoclonal
ApplicationsWB, IP, IF, IHC(P), ELISA
Hostmouse
NCBI Full Gene Nameearly endosome antigen 1
TargetEEA1
IsotypeIgG1

Questions and Answers

Can this EEA1 antibody be used for immunofluorescence applications?

Yes, the EEA1 (G-4) antibody has been shown to work in immunofluorescence applications, as evidenced by its use in various studies, including those that analyze early endosomal dynamics and receptor trafficking in cells.

What species can this antibody react with?

The EEA1 antibody is reactive with multiple species, including human, mouse, rat, and non-human primates, making it versatile for studies involving different model organisms.

Has this antibody been utilized in any specific experimental contexts in the literature?

Yes, the EEA1 antibody has been cited in studies investigating endosomal trafficking and receptor-mediated endocytosis, such as its role in TLR4 endocytosis in macrophages during inflammatory responses ().

What is the recommended dilution for using this antibody in Western blotting?

The EEA1 antibody is typically used at a dilution of 1:1000 for Western blotting, as indicated in various publications that have successfully employed this antibody in their experimental setups.

Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Endolysosomal two-pore channels regulate a conserved entry pathway for enterovirusesJ Gen VirolJuly 15, 2026Ta-Chou Weng, Bang-Yan Hsu, Tung-Heng Wu, Xin-Ya Gu, Hsu-Hung Cheng, Szu-Hao Kungfor endosomal markers using EEA1 (early endosome antigen 1) Alexa Fluor 546 antibody (G-4, 1 : 500; sc-137130, Santa Cruz) to identify early endosomes. Cells were co-stained with LAMP1 (lysosomal-associated membrane

(2) Pictilisib and nutrient stress synergize to induce methuosis via PI(4,5)P2-dependent macropinocytic dysregulation in cancer cellsCell Death & DiseaseJune 16, 2026Xuefei Wang, Xiaolin Sang, Yuemei Wen, Xingming Liao, Jiao Liu, Tiezheng Zheng, Tianming Xing, Min Wang, Dong An, Xining Zhang, et al.and DAPI solution (Sigma-Aldrich) were used for visualization. The primary antibodies included EEA1 (sc-137130, Santa Cruz, USA), Rab7 (CST#95746), PI(4,5)P2 (ab11039, Abcam). Fluorescence images were acquired using

(3) Peroxisome-derived ether lipids regulate lysosomal exocytosisThe EMBO JournalMay 2, 2026Liang Chen, Danielle Henn, Zhongzheng Dong, Jiaxuan Liang, Aleksander Wielenga, Goncalo Vale, Bala Burugula, Junyi Zou, Yamuna Krishnan, Jeffrey G McDonald, et al.134723-1-AP Rabbit anti-Golga3,Proteintech,Cat# 21193-1-AP Mouse anti-EEA1,Santa Cruz Biotechnology,Cat# sc-137130 Rabbit anti-VDAC1/2,Proteintech,Cat# 10866-1-AP Mouse anti-PMP70,Abcam,Cat# ab3421 Rabbit anti-CTSD,Proteintech,Cat#

(4) Picalm coordinates clathrin-mediated endocytosis and actin remodeling during myogenesisMolecular metabolismMay 1, 2026Gaugel J, Haacke N, Kuropka B, Jähnert M, Rominger J, Jonas W, Speckmann T, Rausch N, Kleinert M, Weigert C, et al.,Santa Cruz,sc-271224 Mymx (ESPG),Polyclonal,Sheep,Invitrogen,PA5-47639 EEA1,Monoclonal,Mouse,Santa Cruz,sc-137130 Adaptin alpha (subunit of AP-2),Monoclonal,Mouse,BD transduction lab,610501 Vamp3,Polyclonal,Rabbit,Synaptic systems

(5) Cepharanthine inhibits enterovirus entry by endolysosomal deacidification and exhibits protective activity in vivoAntimicrobial Agents and ChemotherapyDecember 10, 2025Ta-Chou Weng, Bang-Yan Hsu, Szu-Hao Kungsecondary Ab. Additionally, cells were co-stained with either EEA1 Ab Alexa Fluor 546 (G-4, 1:500, sc-137130, Santa Cruz) or LAMP1 Ab Alexa Fluor 546 (H4A3, 1:500, sc-20011, Santa Cruz). The cells were also stained

(6) Snord15b Maintains Stemness of Intestinal Stem Cells via Enhancement of Alternative Splicing of Btrc Short Isoform for Suppression of β‐Catenin UbiquitinationAdvanced ScienceNovember 1, 2025Yuwei Xu, Peikang Zhang, Zhen Xiong, Yufei Lan, Hui Guo, Runyuan Wu, Cunzhen Li, Hongzhe Fan, Ying Du, Xiaoxiao Zhu, et al.Cell Signaling Technology. Anti‐OLFM4 (Cat# NBP2‐24535SS) was purchased from NOVUS. Anti‐EEA1 (Cat# sc‐137130) was from Santa Cruz. Anti‐β‐actin (Cat# A1978) and Anti‐Flag (Cat# F1804) antibodies were from Sigma‐Aldrich.

(7) Rab21 recruits EEA1 and competes with Rab5 for Rabex-5 activationFrontiers in Cell and Developmental BiologyMay 30, 2025Francisco Yanguas, Cinzia Progida37°C and 5% CO2. Antibodies and constructs Primary antibodies used were: Anti-EEA1 from Santa Cruz (sc-137130) was diluted 1:1,000 for Western blot and 1:50 for immunostaining (IF). Anti-tubulin Sigma (T9026) was

(8) Subcellular localization of the P2X4 receptor in sensory hair cells of Wistar rat cochleaHistochem Cell BiolMay 20, 2025Ziyin Huang, Jacqueline M. Ross, Shelly C. Y. Lin, Prakansha N. Kumar, Kevin Roy, Srdjan M. Vlajkovic, Peter R. Thorne, Haruna Suzuki-Kerret al., 2019), (Oh et al. 2020)" "Anti-EEA-1, mouse IgG monoclonal",Santa Cruz Biotechnology Inc. (sc-137130),N-terminus of human EEA1,1:200,"Mouse, rat, human and monkey",Endosomes,"(Kuszczyk et al. 2013), (Men

(9) N-Myc downstream regulated gene 1b is a regulator of cell adhesion during early muscle developmentBIORXIVMay 13, 2025P.K. Chowdhary, R.M. Brewsterantibodies: anti-N-cadherin (1:100, Abcam, Cat #ab211126); anti-EEA1 (1:100, Santa Cruz Biotechnology, Cat #sc-137130); anti-mGFP/mEGFP (1:100, Abcam, Cat #1218). Secondary antibodies: Goat anti-Rabbit IgG (H+L) Highly Cross-Adsorbed

(10) DSTYK phosphorylates STING at late endosomes to promote STING signalingEMBO ReportsFebruary 20, 2025Hao Dong, Heng Zhang, Pu Song, Yuan Hu, Danying Chenmonoclonal anti-Rab7,Santa Cruz Biotechnology,sc-376362 Mouse monoclonal anti-EEA1,Santa Cruz Biotechnology,sc-137130 Rabbit monoclonal antibodies to phospho-IRF3 (S386),Abcam,ab76493 Rabbit monoclonal anti-phospho-TBK1/NAK

(11) Listerin promotes α-synuclein degradation to alleviate Parkinson's disease through the ESCRT pathwaySci AdvFebruary 14, 2025Fei Qin, Runyu Cao, Wenjing Cui, Xuemei Bai, Jiahua Yuan, Yuling Zhang, Yaxing Liu, Nan Cao, Na Dong, Min Zhou, et al.Cruz Biotechnology, SC-53955), anti-Listerin (Abcam, ab104375), anti-EEA1 (Santa Cruz Biotechnology, SC-137130), anti-RAB7 (Santa Cruz Biotechnology, SC-376362), anti-Flag (Sigma-Aldrich, F1804), anti-Flag (Invitrogen,

(12) Tropomodulin1 exacerbates inflammatory response in macrophages by negatively regulating LPS-induced TLR4 endocytosisCellular and Molecular Life SciencesDecember 1, 2024Xueyu Geng, Xue Xia, Zhenhui Liang, Shuo Li, Zejun Yue, Huan Zhang, Lina Guo, Shan Ma, Siyu Jiang, Xiang Lian, et al.(#A5258) was purchased from Abclonal (Wuhan, China). Antibodies for early endosomal antigen 1 (EEA1, #sc-137130), and lysosome-associated membrane protein 1 (LAMP-1, #sc-20011) were obtained from Santa Cruz Biotechnology.

(13) Inhibition of cathepsin L ameliorates inflammation through the A20/NF-κB pathway in endotoxin-induced acute lung injuryiScienceNovember 15, 2024Shiyi Yang, Kaijun Chen, Jinkang Yu, Zhangchu Jin, Min Zhang, Zhouyang Li, Yang Yu, Nanxia Xuan, Baoping Tian, Na Li, et al.AB_2687580 CTSL,Sigma-Aldrich,Cat#C4618; RRID: AB_1078407 EGFR,Abcam,Cat#ab52894; RRID: AB_869579 EEA1,Santa Cruz,Cat#sc-137130; RRID: AB_2246349 TFEB,Abcam,Cat#ab122910; RRID: AB_10901928 IKKα/β,Abcam,Cat#EPR16628; RRID: AB_2924430 IKKγ/NEMO,Cell Signaling Technology

(14) Loss of tumor suppressor TMEM127 drives RET-mediated transformation through disrupted membrane dynamicsElifeApril 30, 2024Timothy J Walker, Eduardo Reyes-Alvarez, Brandy D Hyndman, Michael G Sugiyama, Larissa CB Oliveira, Aisha N Rekab, Mathieu JF Crupi, Rebecca Cabral-Dias, Qianjin Guo, Patricia LM Dahia, et al.(#sc-94, RRID:AB_2140110), pERK (#sc-7383, RRID:AB_627545), EGFP (#sc-9996, RRID:AB_627695), and EEA1 (#sc-137130, RRID:AB_2246349) were from Santa Cruz Biotechnology (Dallas, TX, USA). The anti-γ-tubulin (#T6557,

(15) Loss of tumor suppressor TMEM127 drives RET-mediated transformation through disrupted membrane dynamicseLifeApril 30, 2024Timothy J Walker, Eduardo Reyes-Alvarez, Brandy D Hyndman, Michael G Sugiyama, Larissa C B Oliveira, Aisha N Rekab, Mathieu J F Crupi, Rebecca Cabral-Dias, Qianjin Guo, Patricia L M Dahia, et al.(#sc-94, RRID:AB_2140110), pERK (#sc-7383, RRID:AB_627545), EGFP (#sc-9996, RRID:AB_627695), and EEA1 (#sc-137130, RRID:AB_2246349) were from Santa Cruz Biotechnology (Dallas, TX, USA). The anti-γ-tubulin (#T6557,

(16) OXR1 maintains the retromer to delay brain aging under dietary restrictionNature communicationsJanuary 11, 2024Wilson KA, Bar S, Dammer EB, Carrera EM, Hodge BA, Hilsabeck TAU, Bons J, Brownridge GW 3rd, Beck JN, Rose J, et al.1:100,Validated by neuronal specificity Mouse monoclonal anti-EEA1 [G-4],Santa Cruz Biotechnology,Cat#sc-137130,ICC concentration: 1:100,Validated by company (Santa Cruz Biotechnology) Mouse monoclonal anti-ATP5A

(17) Loss of Tumour Suppressor TMEM127 Drives RET-mediated Transformation Through Disrupted Membrane DynamicsbioRxivDecember 19, 2023Timothy J. Walker, Eduardo Reyes-Alvarez, Brandy D. Hyndman, Michael G. Sugiyama, Larissa C.B. Oliveira, Aisha N. Rekab, Mathieu J.F. Crupi, Rebecca Cabral-Dias, Qianjin Guo, Patricia L.M. Dahia, et al.(#sc-1290), β-Actin (#sc-47778), EGFR (#sc-120), ERK1 (#sc-94), pERK (#sc-7383), EGFP (#sc-9996), and EEA1 (#sc-137130) were from Santa Cruz Biotechnology (Dallas, TX, USA). The anti-γ-Tubulin (#T6557) antibody was from

(18) The SGK3-Catalase antioxidant signaling axis drives cervical cancer growth and therapy resistanceRedox BiologyNovember 1, 2023Min Wang, Jiannan Liu, Xingming Liao, Yasong Yi, Yijue Xue, Ling Yang, Hailing Cheng, Pixu Liu(Proteintech# 66008-4-Ig, 1:1000), HA-tag (CST#3724, 1:1000), HA-tag (CST#2367, 1:100), EEA1 (Santa Cruz# sc-137130,1:300). 4.13 Cell viability assays Cells were seeded in 96-well plates and then subjected to drug

(19) PP2A methylesterase PME-1 suppresses anoikis and is associated with therapy relapse of PTEN-deficient prostate cancersMolecular oncologyJune 1, 2023Aakula A, Isomursu A, Rupp C, Erickson A, Gupta N, Kauko O, Shah P, Padzik A, Pokharel YR, Kaur A, et al.1 : 1000; p‐Lamin‐A/C S392, Abcam ab58528, Western blotting 1 : 5000; EEA1, Santa Cruz Biotechnology sc‐137130 [G4], Immunofluorescence 1 : 100; p‐FAK Y397, Cell Signaling Technology #8556, Immunofluorescence 1 : 100

(20) EGFR-TNFR1 pathway in endothelial cell facilitates acute lung injury by NF-κB/MAPK-mediated inflammation and RIP3-dependent necroptosisInternational immunopharmacologyApril 1, 2023Zhang H, Zhang X, Ling C, Liu C, Hua S, Xiong Z, Zhao H, Feng Q, Feng Z, Tang J, et al.

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EEA1 (G-4) Antibody

EEA1 (G-4) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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EEA1 (G-4) Antibody from Santa Cruz Biotechnology, Inc.

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