MyBioSource.com's Goat Polyclonal to Human PYCARD / ASC is a Goat Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot. The Goat Polyclonal to Human PYCARD / ASC Antibody was generated using PYCARD as the antigen and it reacts with Human, and Non-Human Primate.
Description
Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, BCL10, Apaf-1, ARC, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified in human and mouse and designated ASC and TMS1. Ectopic expression of ASC/TMS1 induced apoptosis through activation of caspase-9 and inhibited the survival of human breast cancer cells