The Rabbit Anti-JAK3 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to JAK3, and Janus kinase 3. This antibody recognizes Mouse antigen. The Rabbit Anti-JAK3 Antibody has been shown to work in the following applications: Western Blot.
Description
Janus Kinase 3 (Jak3) belongs to the Jak family of protein tyrosine kinases that couple to cytokine receptors and are activated by ligand binding to these receptors. Also known as Leukocyte Janus Kinase (LJak), Jak3 is activated after binding to the gamma chain of Interleukin receptors, specifically the IL-2 and IL-4 receptors. Activation of Jak3 is associated with the rapid tyrosine phosphorylation of STAT proteins. Defects in Jak3 cause an autosomal severe combined immunodeficiency disease (SCID)