The Mouse Anti-Human CD44-LE/AF Antibody from MyBioSource.com is a Mouse Monoclonal antibody to CD44. This antibody recognizes Human antigen. The Mouse Anti-Human CD44-LE/AF Antibody has been shown to work in the following applications: Purification, Removal, Block/Neutralize/Inhibit, Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunohistochemistry - fixed, Immunoprecipitation, Western Blot, and Other.
Description
CD44, also known as phagocytic glycoprotein-1 (Pgp-1), exists as a large number of different isoforms resulting from alternative RNA splicing. The major isoform expressed on lymphocytes, myeloid cells, and erythrocytes is a glycosylated type I transmembrane protein. Other variable isoforms containing glycosaminoglycans have molecular weights ranging from 110 to 250 kDa and are widely expressed on hematopoietic and non-hematopoietic cells. CD44 contributes to the adhesion of leukocytes to endothelial cells, stromal cells, and the extracellular matrix. It also plays a functional role in cell migration, lymphocyte homing, and adhesion during hematopoiesis and lymphocyte activation