The RUNX2 Antibody BIOTIN-Conjugated from MyBioSource.com is a Rabbit Polyclonal antibody to RUNX family transcription factor 2, and RUNX2. This antibody recognizes Human, Bovine, Non-Human Primate, and Other Mammalian antigen. The RUNX2 Antibody BIOTIN-Conjugated has been shown to work in the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
BIOTIN-Conjugated Runt-related transcription factor 2 isoform 4 Antibody
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation