MyBioSource.com's Rabbit Anti-4E Binding Protein 1 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot.
Description
4E-BP1 (also known as PHAS-1) normally binds eIF4E, inhibiting cap-dependent translation. Hyperphosphorylation of 4E-BP1 disrupts this binding, activating cap-dependent translation (1). The PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 (2,3). 4E-BP1 is phosphorylated in vivo on multiple residues (4); phosphorylation by FRAP/mTOR on Thr37 and Thr46 of human 4E-BP1 may prime it for subsequent phosphorylation at sites including Ser65 and Thr70 (5)