The b-Amyloid Precursor Protein, CT (APP) Antibody from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human, Mouse, and Rat antigen. The b-Amyloid Precursor Protein, CT (APP) Antibody has been shown to work in the following applications: Western Blot.
Description
Deposition of Amyloid A4 protein precursor (APP) intraneuronally as neurofibrillary tangles, extracellularly as plaques, and in blood vessels is characteristic of both Alzheimerís disease (AD) and aged Downís Syndrome (1). The major protein found in these deposits is a small, insoluble, and highly aggregating polypeptide called amyloid beta peptide (Abeta) that is thought to be derived from aberrant catabolism of its precursor (1). Accumulation of Abeta in the cerebral cortex is a critical event in the pathogenesis of AD (2). APP is cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99 amino acid carboxy fragment (C99) (2). The C99 fragment serves as a substrate for an unknown gamma-secretase to generate the 4kD (approximately 40-42 amino acids) Abeta which forms the plaque core in AD (3). There are five forms of APP found; APP395, APP563, APP695, APP751, and APP770. They are produced by alternative splicing of the APP gene. APP695 is the most predominant form in neuronal tissue while APP751 is the predominant form found elsewhere