MyBioSource.com's Rabbit Anti-SMO / Smoothened Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot. The Rabbit Anti-SMO / Smoothened Antibody was generated using SMO as the antigen and it reacts with Human, Mouse, and Rat.
Description
Smoothened, a Frizzled Receptor, is homologous to the Drosophila segment polarity Smo gene. It associates with the Patched protein to mediate the cellular response to the Hedgehog secreted protein signal, which controls patterning and growth during vertebrate development. Smoothened is activated in a number of human tumors and can function as an oncogene in basal-cell carcinomas