The Rabbit Anti-CASR/Calcium Sensing Receptor Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to Casr. This antibody recognizes Human, and Rat antigen. The Rabbit Anti-CASR/Calcium Sensing Receptor Antibody has been shown to work in the following applications: Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
CASR, a Calcium-Sensing Receptor, functions as a sensor in parathyroid and kidney to determine extracellular calcium concentration and to maintain calcium homeostasis. This receptor regulates both secretion of parathyroid hormone and excretion of urinary calcium. Mutations that inactivate CASR cause familial hypocalciuric hypercalcemia, which is also correlated with hyperparathyroidism. On the other hand, mutations that activate CASR cause autosomal dominant hypocalcemia. Hjalm et al