The Rabbit Anti-HDAC7 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to HDAC7. This antibody recognizes Human, Mouse, and Rat antigen. The Rabbit Anti-HDAC7 Antibody has been shown to work in the following applications: Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
Human HDAC7 is composed of 912 amino acid residues. Although HDAC7 is localized mostly to the cell nucleus, it is also found in the cytoplasm, suggesting nucleo-cytoplasmic shuttling. The histone deacetylase activity of HDAC7 maps to a carboxy-terminal domain and is dependent on interaction with class I HDACs in the nucleus. HDAC7 catalyzes removal of acetyl-groups from acetyl-lysines of histones and promotes compaction of chromatin in these regions, leading to the inhibition of gene transcription