MRE11 (18) Antibody sc-135992 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemMRE11 (18) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-135992
Antibody TypePrimary Antibodies
NCBI Gene AliasesMre11b, MRE11B, MRE11A, Mre11, HNGS1, ATLD
Clone18
Quantity200 µg/ml
ApplicationsWB, IP, IF
Conjugate/TagUnconjugated
ClonalityMonoclonal
FormatPurified
Reactivitymouse, rat, human
Hostmouse
NCBI Full Gene NameMRE11 homolog, double strand break repair nuclease, MRE11A homolog A, double strand break repair nuclease
TargetMRE11
IsotypeIgG1

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Polθ activity modulates sensitivity to standard therapies in DNMT3A-deficient leukemiaCell Rep MedMarch 17, 2026Bac Viet Le, Umeshkumar Vekariya, Monika M. Toma, Margaret Nieborowska-Skorska, Marie-Christine Caron, Malgorzata Gozdecka, Zayd Haydar, Martin Walsh, Jayashri Ghosh, Elaine Vaughan-Williams, et al.680CW,LI-COR,Cat#926–68073; RRID: AB_10954442 Mouse monoclonal anti-MRE11,Santa Cruz Biotechnology,Cat#sc-135992; RRID: AB_2145244 Mouse monoclonal anti-EXO1,Santa Cruz Biotechnology,Cat#sc-56092; RRID: AB_783300 Rabbit

(2) The nuclease EXO1 promotes genomic instability by degrading nascent DNA in BRCA-proficient cellsNature communicationsFebruary 25, 2026Nusawardhana A, Nicolae CM, Moldovan GL.sc-47724; SMARCAL1: Invitrogen PA5-54181; ZRANB3: Novus NBP2-93301; MRE11: Santa Cruz Biotechnology sc-135992; PRIMPOL: Proteintech 29824-1-AP. Functional assays Neutral and BrdU alkaline comet assays were performed

(3) βTrCP facilitates MRN complex localization on chromatin to enhance DNA repairCommun BiolJuly 11, 2025Alejandro Belmonte-Fernández, Joaquín Herrero-Ruíz, Carmen Sáez, Miguel Á. Japón, Mar Mora-Santos, Francisco Romero#12013819001, Roche, Basel, Switzerland); anti-β actin (1:5000; sc-47778 HRP) and anti-MRE11 (1:1000; sc-135992) monoclonal antibodies (Santa Cruz Biotechnology, Dallas, TX, USA); anti-α tubulin (1:20000; T9026)

(4) Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signalingImmunityAugust 9, 2022Xian H, Watari K, Sanchez-Lopez E, Offenberger J, Onyuru J, Sampath H, Ying W, Hoffman HM, Shadel GS, Karin M.

(5) Evidence of requirement for homologous-mediated DNA repair during Ambystoma mexicanum limb regenerationDevelopmental dynamics : an official publication of the American Association of AnatomistsJune 1, 2022García-Lepe UO, Torres-Dimas E, Espinal-Centeno A, Cruz-Ramírez A, Bermúdez-Cruz RM.

(6) O-GlcNAc transferase couples MRE11 to transcriptionally active chromatin to suppress DNA damageJournal of biomedical scienceFebruary 14, 2022Gondane A, Girmay S, Helevä A, Pallasaho S, Loda M, Itkonen HM.

(7) The Targeting of MRE11 or RAD51 Sensitizes Colorectal Cancer Stem Cells to CHK1 InhibitionCancersApril 19, 2021Mattiello L, Soliman Abdel Rehim S, Musella M, Sistigu A, Guarracino A, Vitale S, Corradi F, Galassi C, Sperati F, Manic G, et al.were incubated with primary antibodies directed against MRE11 (1:1000; #sc-22767; RRID:AB_2145247 and #sc-135992; RRID:AB_2145244) from Santa Cruz Biotechnology (Dallas, TX, USA), PARP1 (#9542) from Cell Signaling Technology

(8) An ATM-Chk2-INCENP pathway activates the abscission checkpointThe Journal of cell biologyFebruary 1, 2021Petsalaki E, Zachos G.

(9) Rotavirus activates a noncanonical ATM-Chk2 branch of DNA damage response during infection to positively regulate viroplasm dynamicsCellular microbiologyMarch 1, 2020Sarkar R, Patra U, Lo M, Mukherjee A, Biswas A, Chawla-Sarkar M.

(10) Recruitment of DNA Repair MRN Complex by Intrinsically Disordered Protein Domain Fused to Cas9 Improves Efficiency of CRISPR-Mediated Genome EditingBiomoleculesOctober 8, 2019Reuven N, Adler J, Broennimann K, Myers N, Shaul Y.

(11) MicroRNA-130a modulates a radiosensitivity of rectal cancer by targeting SOX4Neoplasia (New York, N.Y.)September 1, 2019Ha Thi HT, Kim HY, Kim YM, Hong S.

(12) The BRCT Domains of the BRCA1 and BARD1 Tumor Suppressors Differentially Regulate Homology-Directed Repair and Stalled Fork ProtectionMolecular cellOctober 4, 2018Billing D, Horiguchi M, Wu-Baer F, Taglialatela A, Leuzzi G, Nanez SA, Jiang W, Zha S, Szabolcs M, Lin CS, et al.

(13) Cyclin A2 regulates homologous recombination DNA repair and sensitivity to DNA damaging agents and poly(ADP-ribose) polymerase (PARP) inhibitors in human breast cancer cellsOncotargetOctober 31, 2017Gu WW, Lin J, Hong XY.

(14) Identification of two novel BRCA1-partner genes in the DNA double-strand break repair pathwayBreast cancer research and treatmentOctober 1, 2013Guglielmi C, Cerri I, Evangelista M, Collavoli A, Tancredi M, Aretini P, Caligo MA.

(15) Effects on human transcriptome of mutated BRCA1 BRCT domain: a microarray studyBMC cancerMay 30, 2012Iofrida C, Melissari E, Mariotti V, Guglielmi C, Guidugli L, Caligo MA, Pellegrini S.Cancer 2012, 12:207 http://www.biomedcentral.com/1471-2407/12/207 Page 4 of 11 monoclonal antibody 18: sc-135992, Santa Cruz Biotechnology, Inc., Santa Cruz, CA, USA, dilution 1:500); NFKB1 (anti-NFKB1 mouse monoclonal

(16) Increased PARP-1 association with DNA in alkylation damaged, PARP-inhibited mouse fibroblastsMolecular cancer research : MCRMarch 1, 2012Kedar PS, Stefanick DF, Horton JK, Wilson SH.(#611870) was from BD Biosciences Pharmingen (San Diego, CA). Mouse monoclonal anti-MRE11 antibody (sc-#135992), rabbit polyclonal anti-ATR antibody (sc-#28901) and mouse monoclonal anti-lamin A/C antibody (sc-7293)

(17) Different expression of alternative lengthening of telomere (ALT)-associated proteins/mRNAs in osteosarcoma cell linesOncology lettersNovember 1, 2011Zhang Y, Cai L, Wei RX, Hu H, Jin W, Zhu XB.(ab5181, Abcam, Boston, MA, USA); mouse monoclonal anti-PML (sc-966), anti-FEN1 (sc-28355), anti‑MRE11 (sc-135992) and anti-Rad52 (sc-365341) (all three purchased from Santa Cruz Biotechnology, Santa Cruz, CA, USA);

(18) Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP-ribosyltransferase PARP14 in DNA replication dynamics controlled by ATRNucleic acids researchJanuary 1, 0001"Dhoonmoon A, Schleicher EM, Clements KE, Nicolae CM, Moldovan GL."sc-377150); Chk1 (Cell signaling Technology 2360); DNA2 (Abcam ab96488); MRE11 (Santa Cruz Biotechnology sc-135992); TOPBP1 (Novus NB100-217); GAPDH (Santa Cruz Biotechnology sc-47724); γH2AX (Abcam ab-2893). The chemical

(19) PKCδ Regulates Chromatin Remodeling and DNA Repair through SIRT6Molecular cancer research : MCRJanuary 1, 0001"Affandi T, Haas A, Ohm AM, Wright GM, Black JC, Reyland ME."# sc-166488, RRID:AB_2152940), anti-SIRT6 (Cat # sc-517556, RRID:AB_2915920), and anti-Mre11 (Cat # sc-135992, RRID:AB_2145244) from Santa Cruz Biotechnology; anti-Artemis (Cat # NBP2–44276, RRID:AB_2915919), anti-β-tubulin

(20) SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cellsCell death & diseaseJanuary 1, 0001"Na J, Newman JA, Then CK, Syed J, Vendrell I, Torrecilla I, Ellermann S, Ramadan K, Fischer R, Kiltie AE."abcam, Cambridge, UK), anti-MRE11 C-terminal (ab227452; abcam, Cambridge, UK), anti-MRE11 N-terminal (sc-135992; Santa Cruz, Dallas, TX), anti-myc-tag (2276 S; CST, Danvers, MA), anti-phospho-histone H2A.X (Ser139)

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MRE11 (18) Antibody

MRE11 (18) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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MRE11 (18) Antibody from Santa Cruz Biotechnology, Inc.

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