MyBioSource.com's Mouse Anti-Complement C3, C3d Antibody is a Mouse monoclonal antibody. The Mouse Anti-Complement C3, C3d Antibody was generated using C3, and complement C3 as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: EIA, Immunoassay, ELISA, Flow Cytometry, Immunohistochemistry, and Western Blot.
Description
Human complement component 3d (C3d) is a 33kD polypeptide fragment generated over the course of complement activation where complement 3 (C3) convertases cleave C3 to C3b, which is further degraded into iC3b and C3dg/C3d. C3d is involved in the regulation of many aspects of the immune response, including antigen processing and presentation. The C3d/antigen complex mediates B cell activation by simultaneously binding antigen-specific surface bound immunoglobulin and CD21, lowering the complement activation threshold. C3 is crucial in the induction of tolerance generated when an antigen is introduced into immunoprivileged sites and this is exploited by pathogens and cancer cells to evade the immune system by inhibiting complement activation