MyBioSource.com's Rabbit Polyclonal to Human SYVN1 / HRD1 is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed. The Rabbit Polyclonal to Human SYVN1 / HRD1 Antibody was generated using synoviolin 1 as the antigen and it reacts with Human, Mouse, Rat, Bovine, Canine, Hamster, Horse, Non-Human Primate, Rabbit, Xenopus/Amphibian, Zebrafish/Fish, and Other Mammalian.
Description
HRD1, a Ubiquitin-protein ligase (E3), is required for the degradation and ubiquitination of several endoplasmic reticulum-associated degradation (ERAD) substrates and physically associates with relevant ubiquitin-conjugating enzymes (E2s). Human HRD1 is localized to the ER and ubiquitinates its substrates. HRD1 has been suggested to be up-regulated to protect against ER stress-induced apoptosis by degrading unfolded proteins accumulated in the ER