MyBioSource.com's Rabbit Polyclonal to Human MAPK3 / ERK1 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed. The Rabbit Polyclonal to Human MAPK3 / ERK1 Antibody was generated using MAPK3 as the antigen and it reacts with Human, Mouse, Rat, Bovine, Canine, Hamster, Horse, Non-Human Primate, and Porcine.
Description
ERK1, a MAPK -type protein kinase, is a member of the Ras-MAPK pathway. This pathway modulates the activity of transcription factors, structural proteins, and other protein kinases, leading to biological responses such as cell proliferation and differentiation. Inactive ERK1 associates with MAPK/ERK kinases (MEK) 1 and 2 in the cytosol. Upon stimulation, MEK1/2 phosphorylates and activates ERK1 causing dissociation of the MEK/ERK complex