The Rabbit Anti-Vascular Endothelial Growth Factor Receptor 2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to KDR. This antibody recognizes Mouse antigen. The Rabbit Anti-Vascular Endothelial Growth Factor Receptor 2 Antibody has been shown to work in the following applications: ELISA, and Western Blot.
Description
Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR/FLK-1) is a 200kD member of a receptor tyrosine kinase family whose activation plays an essential role in a large number of biological processes such as embryonic development, wound healing, cell proliferation migration and differentiation. Like other growth factor receptors upon ligand binding, VEGFR2 forms a dimer and is autophosphorylated on multiple tyrosine residues. These sites can be involved in the regulation of kinase activity or serve as binding sites for SH2- and phosphotyrosine bindingcontaining signaling proteins. Phosphorylation of tyrosines 1054 and 1059 in the activation loop is required for activation of VEGFR2 and its intrinsic tyrosine kinase activity