The Rabbit Anti-ZO-1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to Tight Junction Protein 1, and TJP1. This antibody recognizes Human, Mouse, Rat, Canine, and Guinea Pig antigen. The Rabbit Anti-ZO-1 Antibody has been shown to work in the following applications: ELISA, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
ZO-1 is a peripheral membrane protein that is associated with tight junctions (zonula occludentes) which are found on the cytoplasmic surface of epithelial and endothelial cell membranes. ZO-1 has a MW of 225kD and is found in two isoforms that differ by the presence or absence of an 80 amino acid region known as 'motif-a'. These two isoforms are the basis for determining two classes of tight junctions. ZO-1 is known to interact with ZO-2. ZO-1 is homologous to dlg, the Drosophila tumor suppressor. Both are members of a putative signal transduction protein family whose members contain a SH3 domain and a domain homologous to the enzyme guanylate kinase