The Furin Convertase Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to FURIN. This antibody recognizes Human antigen. The Furin Convertase Antibody has been shown to work in the following applications: Immunoprecipitation, and Western Blot.
Description
Furin is a membrane-associated, calcium-dependent, serine protease that belongs to the subtilisin-like prohormone convertase (PC) family. Members of this family of cellular enzymes cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs. Furin and other PC family members share structural similarities which include a heterogeneous ~10kD amino-terminal proregion, a highly conserved ~55kD subtilisin-like catalytic domain, and carboxyl-terminal domain that is heterogeneous in length and sequence. These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment. Furin is the only known PC to possess a transmembrane domain