The Reelin Antibody from MyBioSource.com is a Goat Polyclonal antibody to Reelin, and RELN. This antibody recognizes Mouse antigen. The Reelin Antibody has been shown to work in the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
Reelin is a 400kD, extracellular matrix glycoprotein secreted by several neurons. It is a serine protease that degrades fibronectin and laminin. Reelin also binds lipoprotein receptor superfamily members APOER2 and VLDLR which transduce signals important for neuronal positioning during brain development and synaptic plasticity in the adult brain. In vivo, Reelin undergoes proteolytic processing at two sites, generating three Reelin fragments. The N-terminal domain binds integrin alpha3/beta1, leading to a disruption of neuronal glial cell interactions and inhibition of neuronal migration. Mouse Reelin shares 94% and 96% amino acid identity with human and rat Reelin, respectively in the region immunized