Rabbit Anti-4E Binding Protein 1 Antibody MBS628900 from MyBioSource.com

Description

4E-BP1 (also known as PHAS-1) normally binds eIF4E, inhibiting cap-dependent translation. Hyperphosphorylation of 4E-BP1 disrupts this binding, activating cap-dependent translation. The PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1. 4E-BP1 is phosphorylated in vivo on multiple residues; phosphorylation by FRAP/mTOR on Thr37 and Thr46 of human 4E-BP1 may prime it for subsequent phosphorylation at sites including Ser65 and Thr70

Product Specs
ItemRabbit Anti-4E Binding Protein 1 Antibody
CompanyMyBioSource.com
Price $695.00Supplier Page View Company Product Page
Catalog NumberMBS628900
Quantity0.1 mL
ApplicationsELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP)
Conjugate/TagUnconjugated
FormatSupplied as liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA 50% glycerol. No preservative added
PurityAffinity Purified
Purified by Protein A affinity chromatography and immunoaffinity chromatography
ReactivityHuman, Monkey, Mouse, Rat
Target4E Binding Protein 1
IsotypeIgG
Molecular Weight15-20kD
HostRabbit
ImmunogenRecognizes endogenous levels of mouse 4E-BP1 only when phosphorylated at Ser65. Has also been shown to recognize 4E-BP1 when phosphorylated at serine 101. Species Crossreactivity: human, rat and monkey
NCBI Full Gene Nameeukaryotic translation initiation factor 4E binding protein 1
NCBI Gene AliasesBP-1, PHAS-I, 4EBP1, 4E-BP1
ClonalityPolyclonal