MyBioSource.com's Rabbit Anti-c-Abl Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Flow Cytometry, Immunohistochemistry, and Western Blot. The Rabbit Anti-c-Abl Antibody was generated using ABL1 as the antigen and it reacts with Human, and Mouse.
Description
The Bcr gene was orginally identified by its presence in the chimeric Bcr-Abl oncogene (1). The N-terminal region of Bcr contains an oligomerization domain, a serine/threonine kinase domain and a region that binds SH2 domain. The middle of the protein has a PH domain and a region of sequence similarity to the guanine nucleotide exchange factors for the Rho family of GTP binding proteins. The carboxy-terminal region may be involved in a GTPase-activating function for the small GTP-binding protein Rac (2,3). The function of Wild-type Bcr in cells remains unclear. PDGF receptor may use Bcr as a downstrean signal mediator (4). The Bcr-Abl fusion results in production of a constitutively active tyrosine kinase, which causes chronic myelogenous leukemia (CML) (5). Tyrosine 177 of Bcr is phosphorylated in the Bcr-Abl fusion protein, which plays an important role in transforming the activity of Bcr-Abl (6). Phosphorylated Tyr177 of Bcr provides a docking site for Gab2 and GRB2 (7,8)