The CDK2 RMab Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to CDK2. This antibody recognizes Human, and Mouse antigen. The CDK2 RMab Antibody has been shown to work in the following applications: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
CDK2 (also known as Cyclin-dependent kinase 2 or cell division protein kinase 2) is a 33 kDa enzyme that in humans is encoded by the CDK2 gene on Chromosome 12. CDK2 is a catalytic subunit of the cyclin-dependent kinase complex, whose activity is restricted to the G1-S phase of the cell cycle, and is essential for the cellular G1/S transition.Studies indicate that over expression of CDK2 may cause the abnormal regulation of cell-cycle, which would could directly contribute to hyper-proliferation of cancerous cells. HOX genes, which play a key role in cell differentiation and morphogenisis, are regulated by CDK2. Studies have shown that HOXA7 promoted cell proliferation (mediated by cyclin E1/CDK2) is evident in cases of Hepatocellular carcinoma, indicating that CDK2 may prove to be a useful marker in such cases