MyBioSource.com's Rabbit Anti-OATP Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: EIA, Immunoassay, ELISA, and Western Blot. The Rabbit Anti-OATP Antibody was generated using SLCO1A2 as the antigen and it reacts with Human.
Description
Mammalian kidney and liver are critical in maintaining physiological ionic environment. Kidney specializes in removing toxins, drugs, and other organic anions from the blood by a process called "renal secretion". Besides kidney, anionic substrates are also transported in other organs, e.g., choroid plexus, eye, airway, and placenta. Several multispecific OATs (OAT1-3, OAT-K1 and OATK2) and OATPs (organic anion transporting polypeptides; oatp1-3, LST-1, and PGT), have been cloned and characterized from various tissues. OATPs family of proteins share significant sequence homology, and general secondary protein structure (up to 12 transmembrane domains with cytoplasmic N and C-terminus). Rat Oatp, now called oatp1, encodes a protein of 670 aa. Oatp1 was localized at the apical portions of the S3 segment of the proximal tubule, and at the apical surface of the choroid plexus of rat brain. It is also found in liver, lung, skeletal muscle, and colon. It mediates Na+-independent uptake of wide range of amphipathic