The Rabbit Anti-JAK1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to JAK1, and Janus kinase 1. This antibody recognizes Human antigen. The Rabbit Anti-JAK1 Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
Janus Kinase 1 (JAK1) is a 130kD tyrosine kinase involved in cytoplasmic signal transduction. Ligand binding to a variety of cell surface receptors (e.g., cytokine, growth factor, GPCRs) leads to an association of those receptors with JAK proteins, which are then activated via phosphorylation on tyrosines 1022 and 1023 in the kinase activation loop. Activated JAK proteins phosphorylate and activate STAT (signal transducers and activators of transcription) proteins, which then dimerize and translocate to the nucleus. Once in the nucleus, STAT proteins bind to DNA and modify the transcription of various genes, which can lead to various responses such as cell proliferation, cell survival and differentiation