MyBioSource.com's Rabbit Anti-DNAmethyltransferase3A Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry. The Rabbit Anti-DNAmethyltransferase3A Antibody was generated using DNMT3A as the antigen and it reacts with Human.
Description
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development.DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells.Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity