MyBioSource.com's Rabbit Anti-CASR/Calcium Sensing Receptor Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed. The Rabbit Anti-CASR/Calcium Sensing Receptor Antibody was generated using Casr as the antigen and it reacts with Human, Mouse, Rat, Bovine, Canine, Chicken/Bird, Hamster, Horse, Non-Human Primate, Porcine, Rabbit, and Other Mammalian.
Description
CASR, a Calcium-Sensing Receptor, functions as a sensor in parathyroid and kidney to determine extracellular calcium concentration and to maintain calcium homeostasis. This receptor regulates both secretion of parathyroid hormone and excretion of urinary calcium. Mutations that inactivate CASR cause familial hypocalciuric hypercalcemia, which is also correlated with hyperparathyroidism. On the other hand, mutations that activate CASR cause autosomal dominant hypocalcemia. Hjalm et al