The Rabbit Anti-JAK2 Antibody from MyBioSource.com is a Rabbit Monoclonal antibody. This antibody recognizes Human, Mouse, Rat, and Non-Human Primate antigen. The Rabbit Anti-JAK2 Antibody has been shown to work in the following applications: Western Blot.
Description
Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3 and Tyk2) are activated by ligands binding to a number of associated cytokine receptors (1). Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their associated receptors to provide multiple binding sites for signaling proteins. These associated signaling proteins, such as Stats (2), Shc (3), insulin receptor substrates (4) and focal adhesion kinase (FAK) (5), typically contain SH2 or other phospho-tyrosine-binding domains