Fig 2: Overall survival (OS) curves based on the protein expression in PDAC tissues. The graphs show the OS curves based on (A) NF−κB (RelA) nuclear expression, (B) NF−κB (RelA) cytoplasmic expression, (C) COX−2 expression, (D) Sp1 expression, and (E) c−Jun expression. (F) OS curve of patients with co−expressions of all four proteins vs. other patient groups. OS, overall survival; COX−2, Cyclooxygenase−2; NF−κB, Nuclear Factor Kappa−B; and Sp1, Specificity Protein 1.

Fig 3: The difference in NF−κB, COX−2, Sp1, and c−Jun expressions between PDAC tissue and adjacent normal tissue. COX−2, cyclooxygenase−2; NF−κB, nuclear factor kappa−B; and Sp1, specificity protein 1. * p < 0.05.

Fig 4: Correlations between COX−2 and its transcription factors (NF−κB, Sp1, and c−Jun) in PDAC tissues. (A) Positive correlation between COX−2 and cytoplasmic NF−κB expression. (B) Positive correlation between COX−2 and nuclear NF−κB expression. (C) Positive correlation between COX−2 and Sp1 expression. (D) Positive correlation between COX−2 and c−Jun expression. (E) Positive correlation between cytoplasmic and nuclear NF−κB expression. COX−2, cyclooxygenase−2; NF−κB, nuclear factor kappa−B; and Sp1, specificity protein 1. * p < 0.01.