Cannabinoid receptor CB1-R Antibody 258 011 from Synaptic Systems GmbH

Product Specs
ItemCannabinoid receptor CB1-R Antibody
CompanySynaptic Systems GmbH
Price $425.00Supplier Page View Company Product Page
Catalog Number258 011
Quantity100 µg
ApplicationsICC, IHC, IHC-P
Formatlyophilized
Reactivityrat, mouse, human
TargetCannabinoid receptor CB1-R
IsotypeIgG2b
Hostmouse
Clonalitymonoclonal
Cell Line289C1
Clone289C1
ImmunogenSynthetic peptide corresponding to AA 450 to 473 from rat CB1-R
ValidationKO
Antibody TypePrimary antibody

Questions and Answers

Can this antibody be used for immunohistochemistry in my studies on cannabinoid receptors?

Yes, the Cannabinoid receptor CB1-R Antibody has been shown to work effectively in immunohistochemistry applications, as evidenced by its use in studies such as those by Huckleberry et al. (2023) and Kim et al. (2021), where it was utilized to investigate the expression of CB1 receptors in various brain regions.

Is this antibody suitable for use in both male and female animal models?

The Cannabinoid receptor CB1-R Antibody has been utilized in studies involving both male and female rodents. For instance, research by Kim et al. (2022) and Kim et al. (2023) highlights the importance of considering sex differences in cannabinoid receptor pharmacology, indicating that this antibody can be effectively applied in both contexts.

What specific applications has this antibody been validated for in the literature?

The Cannabinoid receptor CB1-R Antibody has been validated for use in immunocytochemistry and immunohistochemistry, as demonstrated in multiple studies, including those by Kim et al. (2021) and Huckleberry et al. (2023), where it was employed to analyze receptor expression and interactions in various experimental setups.

Are there any notable findings related to the use of this antibody in behavioral studies?

Yes, studies utilizing the Cannabinoid receptor CB1-R Antibody have revealed significant insights into the role of cannabinoid receptors in behavior. For example, Huckleberry et al. (2023) explored the effects of CB1 receptor blockade on fear conditioning behaviors, highlighting the antibody's relevance in behavioral neuroscience research.

Synaptic Systems GmbH

Rudolf-Wissell-Str. 28

Goettingen 37079

Germany

Phone: +49-551-50556-0
+49-551-50556-384

Company Profile

Website: http://www.sysy.com/

(1) CB1R blockade unmasks TRPV1-mediated contextual fear generalization in female, but not male ratsNeuropsychopharmacology : official publication of the American College of NeuropsychopharmacologySeptember 1, 2023Huckleberry KA, Calitri R, Li AJ, Mejdell M, Singh A, Bhutani V, Laine MA, Nastase AS, Morena M, Hill MN, et al.shaker. Sections were then incubated with primary antibody (mouse anti-CB1R 1:500, Synaptic Systems, 258 011, 289C1, Lot 1-4 [37–39]) in blocking solution on shaker overnight at 4 °C. Sections were washed the

(2) Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivityNeuronApril 19, 2023Rosenberg EC, Chamberland S, Bazelot M, Nebet ER, Wang X, McKenzie S, Jain S, Greenhill S, Wilson M, Marley N, et al.1:1000,Abcam,Cat#Ab12093 CK α Gephyrin 1:200,Abcam,Cat#Ab136343 MS α CB1R 1:500,Synaptic Systems,Cat#258 011 GP α Tau 1:1000,Synaptic Systems,Cat#314 004 GP α MAP2 1:1000,Synaptic Systems,Cat#188 004 RB α GABAAR

(3) Dual Cannabinoid and Orexin Regulation of Anhedonic Behaviour Caused by Prolonged Restraint StressBrain sciencesFebruary 13, 2023Kim HJJ, Zagzoog A, Ceni C, Ferrisi R, Janz N, Laprairie RB.follows: Cannabinoid Receptor CB1R Monoclonal Antibody (mouse, Synaptic Systems, Göttingen, Germany, Cat #258011, Lot 1–5) diluted in CytoVista™ Antibody Dilution Buffer (Invitrogen, Eugene, OR, Cat #V11305) at 1:500,

(4) Social Play Behavior Is Critical for the Development of Prefrontal Inhibitory Synapses and Cognitive Flexibility in RatsThe Journal of neuroscience : the official journal of the Society for NeuroscienceNovember 16, 2022Bijlsma A, Omrani A, Spoelder M, Verharen JPH, Bauer L, Cornelis C, de Zwart B, van Dorland R, Vanderschuren LJMJ, Wierenga CJ.

(5) Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunctionNature communicationsJune 17, 2022Liu Z, Yang N, Dong J, Tian W, Chang L, Ma J, Guo J, Tan J, Dong A, He K, et al.anti-DRD1 (Sigma-Aldrich, D2944, clone 1-1-F11 s.E6, 1:500), mouse monoclonal anti-CB1 (Synaptic systems, 258011, clone 289c1, 1:500), rabbit polyclonal anti-TH (Pel-Freez Biologicals, P40101, 1:2500), mouse monoclonal

(6) Impact of the mouse estrus cycle on cannabinoid receptor agonist-induced molecular and behavioral outcomesPharmacology research & perspectivesJune 1, 2022Kim HJJ, Zagzoog A, Black T, Baccetto SL, Ezeaka UC, Laprairie RB.cannabinoid receptor CB1R monoclonal antibody (mouse, Synaptic Systems, Göttingen, Germany, Lot 1–3, Cat # 258011) diluted at 1:500, cannabinoid receptor CB2R polyclonal antibody (rabbit, Abcam, Cambridge, United Kingdom,

(7) Axonal CB1 Receptors Mediate Inhibitory Bouton Formation via cAMP Increase and PKAThe Journal of neuroscience : the official journal of the Society for NeuroscienceOctober 6, 2021Liang J, Kruijssen DLH, Verschuuren ACJ, Voesenek BJB, Benavides FFW, Sáez Gonzalez M, Ruiter M, Wierenga CJ.

(8) Early-life stress exacerbates the effects of WIN55,212-2 and modulates the cannabinoid receptor type 1 expressionNeuropharmacologyFebruary 15, 2021Martín-Sánchez A, García-Baos A, Castro-Zavala A, Alegre-Zurano L, Valverde O.

(9) In vivo Evidence for Brain Region-Specific Molecular Interactions Between Cannabinoid and Orexin ReceptorsFrontiers in neuroscienceJanuary 1, 2021Kim HJJ, Zagzoog A, Smolyakova AM, Ezeaka UC, Benko MJ, Holt T, Laprairie RB.cannabinoid receptor CB1R monoclonal antibody (mouse, Synaptic Systems, Göttingen, Germany, Lot 1–3, Cat # 258011) diluted at 1:500, orexin receptor 1 polyclonal antibody (rabbit, Enzo Life Sciences, Farmingdale, NY,

(10) Effects of ∆⁹-THC on memory in ovariectomized and intact female ratsHormones and behaviorJanuary 1, 2021DeLarge AF, Winsauer PJ.primary antibody (rabbit: Cell Signaling (8644), Danvers, MA, 1:200)/CB1 (mouse: Synaptic Systems (258011), Germany, 1:200) solution containing 1% bovine serum albumin (BSA), 0.3% Triton-X and 1x PBS. Slides

(11) A High-Resolution Method for Quantitative Molecular Analysis of Functionally Characterized Individual SynapsesCell reportsJuly 28, 2020Holderith N, Heredi J, Kis V, Nusser Z.anti-CB1,Frontiers,Cat#Af530; RRID: AB_2314113 Mouse monoclonal IgG2b anti-CB1,Synaptic systems,Cat#258 011; RRID: AB_2619969 Rabbit polyclonal anti-CB1,Synaptic systems,Cat#258 003; RRID: AB_2619970 Rabbit

(12) Endocannabinoid Signaling Mediates Local Dendritic Coordination between Excitatory and Inhibitory SynapsesCell reportsApril 16, 2019Hu HY, Kruijssen DLH, Frias CP, Rózsa B, Hoogenraad CC, Wierenga CJ.

(13) The cannabinoid-1 receptor is abundantly expressed in striatal striosomes and striosome-dendron bouquets of the substantia nigraPloS oneJanuary 1, 2018Davis MI, Crittenden JR, Feng AY, Kupferschmidt DA, Naydenov A, Stella N, Graybiel AM, Lovinger DM.RRID:AB_409026" Rabbit Anti-CB1-R,K.Mackie (L15),1:1000, Mouse Anti-CB1-R,Synaptic Systems,1:500,"258 011, RRID:AB_2619969" Rabbit Anti-TH,Abcam,1:4000,Ab112 Rabbit Anti-TH,Thermo,1:500,"AB_297840, RRID:

(14) Relation between the contact time and venous and alveolar PCO2 at restAdvances in experimental medicine and biologyJanuary 1, 1986M Mochizuki, T Kagawa, K Uchida, I Shibuya

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Cannabinoid receptor CB1-R Antibody

Cannabinoid receptor CB1-R Antibody

Cannabinoid receptor CB1-R Antibody

Cannabinoid receptor CB1-R Antibody

Cannabinoid receptor CB1-R Antibody from Synaptic Systems GmbH

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Questions and Answers

Synaptic Systems GmbH

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Cannabinoid receptor CB1-R Antibody from Synaptic Systems GmbH

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