Description
Pressure arteriography is the gold standard for quantifying function, reactivity, and mechanics in isolated perfused blood vessels. When embarking on pressure arteriography, many factors warrant consideration. In addition to the requisite surgical skills for isolating and cannulating small arteries, proper instrumentation is also paramount. Pressure arteriography, while a powerful tool, comprises several different hardware and software components that must be integrated and operated properly.
Living Systems Instrumentation is the only provider of complete pressure arteriography systems that not only allow the researcher to quickly get their experiments up and running but also ensure the quality and reproducibility of the data collected. Not only is LSI the pioneer in pressure arteriography, it also has a long and comprehensive publication history that speaks to its established and state-of-the-art arteriography systems.
While there are other options for individual arteriography components available from various sources, these require significant investment in time to optimize, refine, and “debug” which delays maintaining a regular experiment schedule and often lacks the robustness required for data integrity and confidence.
With its long experiential history and comprehensive knowledge base, Living Systems is always available to assist and support all of your arteriography needs.
Constant Pressure - The vast majority of applications are well-served by constant pressure, no intraluminal flow setup
- The distal end of the vessel is occluded
- Key components include a pressure source, vessel chamber, means for temperature control, and data acquisition hardware/software
Constant Pressure & Flow - Setup for intravascular flow is a bit more complex
- The distal end of the vessel remains open
- In addition to the basic items for regulating intravascular pressure, you will also need a pump to control intraluminal solution flow and a way to monitor pressure on both sides of the cannulated vessel
Parts of a Pressure Arteriography - Vessel is mounted between the cannulae and tied in place with nylon thread (provided with the chamber)
- Cannulae provide access to the lumen of the vessel.
- Blood is flushed out of the vessel
- Superfusion of the desired buffer into the chamber and into the vessel