Magnetic separation may have seen its first use in biological applications as early as the 1970s. The technique, which uses natural or induced magnetic properties, relies on the use of magnetic beads. These spherical particles contain an iron core onto which various substances can be coated with various ligands with binding affinities, such as streptavidin, binding proteins, and antibodies. Magnetic separation can thus be used to purify or isolate biological compounds from a more complex mixture. This includes cleaning up nucleic acids in preparation for sequencing, purifying proteins and antibodies from cell lysates, and isolating specific cell types from blood and other media. It has also previously been used in the diagnostic detection of bacteria and viruses from the blood. This process offers advantages, such as minimal sample contact, low cost, and biologically non-invasive. Browse our catalog of magnetic separation tools listed by various suppliers.
A myriad of advances are helping overcome current challenges.
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Innovative methods are supplementing traditional methods
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The CliniMACS Prodigy automates cell manufacturing workflows from cell separation, cultivation and genetic engineering, to final product formulation, ensuring GMP-compliant, reproducible results. Its closed-system design enhances safety, reduces ...
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Discover the beauty of standardized and automated flow cytometry
The MACSQuant® Analyzer 16 is an easy-to-use instrument designed for scalable and reliable flow cytometry assays. This includes features such as:
Full workflow automation: sample ...
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I used these M-270 carboxylic acid Dynabeads to covalently couple my antibody for immunoprecipitation. Coupling was efficient and the beads gave low background with clean pulldowns.
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My goal was to isolate CD14-positive cells (using positive or negative isolation) and mature them over three days into activated dendritic cells.
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