Hyperion+™ Imaging System from Standard BioTools Inc.

Product Specs
ItemHyperion+™ Imaging System
CompanyStandard BioTools Inc.
Price Get Pricing Get Quote for this Product
Catalog NumberHyperion+
MethodImaging mass cytometry (CyTOF) using mass-tagged antibodies; 40+ protein marker detection
ScaleWhole tissue, single cell
QuantityEA

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Standard BioTools Inc.

2 Tower Place, Suite 2000

South San Francisco, California 94080

United States

Phone: 650 266 6000 | Main
866 359 4354 | Toll-free

Company Profile

Website: http://standardbio.com

(1) Spatial omics illuminates tumor heterogeneityCell Reports MethodsAugust 17, 2026Neha Srinivas, Serap Erdogmus, Gurkan MollaogluPhenoCycler. MS-based methods include imaging mass cytometry (IMC, commercially available as Standard BioTools Hyperion)20 and multiplexed ion beam imaging (MIBI),21 where tissue is stained with a panel of metal-conjugated

(2) Impact of Photodynamic Diagnosis on Immune Cell Infiltration in BCG-treated Non-muscle-invasive Bladder CancerEur Urol Open SciAugust 8, 2026Tine Ginnerup Andreasen, Trine Strandgaard, Tessa Jane Divita, Kristine Young-Halvorsen, Anders Neijber, Lars Dyrskjøtapplied to assess associations between PDD use and T-cell exhaustion [15]. IMC was performed using the Hyperion platform (Standard Biotools) for 36 cancer- and immunology-related protein markers. Cell types were

(3) Amelioration of Acute Oxazolone-Induced Colitis via Oral Administration of EPICERTIN, a Mucosal Healing Biotherapeutic for Inflammatory Bowel DiseaseBiomedicinesAugust 6, 2026Wendy M. Kittle, Micaela A. Henderson, Noel Verjan Garcia, Hong Li, Katarina L. Mayer, Jimmy F. Cifuentes Jimenez, Kelly M. Lee, Kavitha Yaddanapudi, Nobuyuki MatobaCell-ID™ Intercalator-Ir (Standard BioTools, South San Francisco, CA, USA). Tissues were imaged on a Hyperion Imaging System (Standard BioTools), and image analysis was performed using MCD Viewer (version 1.0.5, Standard BioTools)

(4) An Integrated Spatial Multi-Omics Workflow for Sequential RNA and Protein Profiling in FFPE Tumor TissueCancer Res CommunAugust 1, 2026Merrin Mary Eapen, Qanber Raza, Lucy Chhuo, Annabel Faulkner, Abhishek K. Singh, Hao Xu, Atefeh Khakpoor, Erin Coll, Liang Lim, Nick Zabinyakov, et al.wash, slides were dried and stored at 4°C. Image acquisition was performed using the Standard BioTools Hyperion XTi Imaging System (RRID: SCR_023195). Low-resolution scans of whole slides were acquired using preview

(5) Dissecting Immune Determinants in Lesional Skin of Cutaneous T-Cell Lymphoma During Mogamulizumab TherapyCancers (Basel)July 21, 2026Xiao Ni, Wei Han, Niharika Kunta, Meghali Goswami, Jared K. Burks, Ye Zheng, Youn H. Kim, Madeleine Duvicto IMC image acquisition. 2.5. IMC Image Acquisition Imaging mass cytometry was performed on the Hyperion™ XTi Imaging System (Standard BioTools, Boston, MA, USA) at a laser repetition rate of 200 Hz by the

(6) Spatial Omics Technologies in Glioblastoma Research: Principles, Applications, and Best PracticesGenes (Basel)July 18, 2026Maxime Vanmechelen, Chiara Caprioli, Paul M. Clement, Ann Hoeben, Frederik De Smetprotein,Targeted,Single-cell,100+ proteins,FFPE & fresh frozen,Very high protein plexity,Long imaging runs Hyperion MIBI-TOF (Standard Biotools),Metal-tagged antibodies,Protein,Targeted,~200 nm–10 µm,40–50 proteins,FFPE

(7) Epigenetic signatures mark early peripheral human B lineage bifurcation and differential transcriptional profiles in mature populationsNature CommunicationsJuly 14, 2026Chiara Dionisi, Audrey Kelly, Michael J. Pitcher, Sherine H. Kottoor, Alana Dalton, Lucia Montorsi, Pawan Dhami, Michelle Kleeman, Richard J. Ellis, Cynthia Bishop, et al.Iridium Cell-ID Intercalator-Ir (Cat.N. 201192 A, Standard BioTools). Data acquisition was conducted on a Hyperion Imaging System (Fluidigm). Regions of up to 1 mm2 were selected and laser-ablated at 200-Hz frequency at 1 μm/pixel

(8) A tumor profiling resource for ovarian cancer: insights into chemotherapy-driven heterogeneity and personalized treatment strategyNature CommunicationsJuly 13, 2026Francis Jacob, Rebekka Wegmann, Joanna Ficek-Pascual, Ulrike Lischetti, Jack Kuipers, Stéphane Chevrier, Michael Prummer, Nora C. Toussaint, Ilaria Alborelli, Ricardo Coelho, et al.and dried with compressed air. Imaging mass cytometry The IMC data collection was performed using a Hyperion Imaging System from Standard BioTools, operating at a laser frequency of 200 Hz. Raw image data were transformed into

(9) Spatial mapping and senolytic targeting of senescent and disease-associated microglia in aged mouse brain white matterNat AgingJuly 13, 2026Chase M. Carver, Paul T. Gomez, Sonia L. Rodriguez, James T. Redden, Amanda S. Latham, Yooree Ha, Jennifer M. Kachergus, Yi Liu, Ji Shi, Tommy Tran, et al.each metal-conjugated antibody, distinguished by time-of-flight mass cytometer, were acquired by the Hyperion Imaging System (Standard BioTools), reconstructed into an image. Representative images were converted to OME.TIFF files

(10) Hypoxia shapes both therapeutic response and resistance in metastatic clear cell renal cell carcinomaCancer CellJuly 13, 2026Lynda Vuong, Andrew E. Cornish, Jennifer Pfeil, Yash Khandwala, Hui Jiang, Doris X.T. Zheng, Eduardo A. Mascareno, Nicole Rittenhouse, Phillip M. Rappold, Josef Leibold, et al.control adult tonsil and representative ccRCC tissues samples. Image acquisition was conducted using the Hyperion XT and XTi Imaging Systems (Standard BioTools) at 1 μm resolution and 800 Hz laser ablation. Acquisition

(11) A pilot imaging mass cytometry study of cutaneous nerve-immune cell interactions in post-herpetic neuralgiaFront ImmunolJuly 8, 2026Siddhesh N. Telang, Jackson F. Karrasch, Philip M. Finch, Stefanie S. Kogias, Thomas R. O'Neil, Anthony L. Cunningham, Andrew N. Harman, Peter D. Drummond, Paul J. AustinIntercalator-Ir (DVS Sciences, 201192A), rinsed, and air-dried. All immunolabelled sections were imaged using a Hyperion™ Imaging System (Standard BioTools). Regions of interest spanning the dermal-epidermal border were selected following

(12) TERT drives liver tumorigenesis beyond telomere elongationLife Sci AllianceJuly 2, 2026Laura Braud, Julien Vernerey, Arnaud Guille, Pierre Cordier, Clémence Ginet, Tom Egger, Manuel Bernabe, Dmitri Churikov, Quentin Da Costa, Aïda Meghraoui, et al.signature was from Mitsuishi et al (2012a). Imaging Mass Cytometry (IMC) IMC was performed using the Hyperion Imaging System (Standard BioTools), a multiplexed spatial proteomics platform that enables simultaneous detection of

(13) Cellular interaction of mycosis fungoides tumor cells changes from cytotoxic CD8+ T cells in plaques to B cells in tumorsFront ImmunolJuly 2, 2026Veerle A. Merkus, Marieke E. IJsselsteijn, Marie S. N. Chevalier, Sanne de Haan, Vincent van Unen, Cornelis P. Tensen, Abdoel El Ghalbzouri, Anne M. R. Schrader, Ferenc A. Scheeren, Noel F. C. C. de Miranda, et al.demonstrated strong IHC performance were subsequently conjugated to a heavy metal and evaluated using the Hyperion Imaging System (Standard BioTools, San Francisco, CA, USA). The antibodies were conjugated in-house with heavy metal

(14) Multimodal characterisation of spontaneous Merkel cell carcinoma in the endangered Caucasian squirrel (Sciurus anomalus pallescens): integrating spatial transcriptomics, imaging mass cytometry and metagenomic sequencingJ Vet ResJune 30, 2026Peyman Mohammadzadeh, Amin Pilvaieh, Arshia Dousti, Mohammad Reza Salim Bahrami, Farshad Ziaeeenrichment – were performed in Seurat v. 4.3 (14). Imaging mass cytometry This was performed on a Fluidigm Hyperion Imaging System (Standard BioTools, San Francisco, CA, USA). Formalin-fixed, paraffin-embedded tissue sections 4 μm

(15) Spatial immune atlas of breast cancer brain metastasis reveals CD163+ macrophage reprogramming associated with immune escapeJ Immunother CancerJune 24, 2026Jiale Zhu, Junjie Ye, Yulin Ma, Zhirong Lin, Yupeng Wen, Jianpeng Sheng, Mei Yang4°C with the antibody cocktail, slides were counterstained with iridium intercalator and imaged on a Hyperion Imaging System (Standard BioTools) at 1 µm resolution with identical acquisition parameters for all specimens.42 Image

(16) Density-Adjusted Analysis of Cell Interactions to Decipher Tissue Landscape ChangesiScienceJune 19, 2026Misha Siddiqui, Azam Hamidinekoo, Jennifer Y. Tan, Renata Leke, Bader Zarrouki, Nick Trahearn, Yeman Brhane Hagos, Chirine Sakr, Andrea Lampis, Christopher Bagnall, et al.were then fixed and stained with the panel of antibodies shown in key resources table for IMC with the Hyperion system (Standard Biotools, San Francisco, CA, USA) according to the manufacturer’s guidelines. Images

(17) Mechanisms of increased Alzheimer's disease pathology with R47H and R62H TREM2 variantsActa NeuropatholJune 15, 2026Nurun N. Fancy, Nanet Willumsen, Vicky M. N. Chau, Samuel L. Boulger, Harry J. Whitwell, Wenhao Wang, Baptiste Avot, Michael Thomas, Jonathan Talbot-Martin, Stergios Tsartsalis, et al.conjugation was performed using the Maxpar X8 protocol (Standard BioTools). IMC was performed using a Hyperion Imaging Systems First Generation (Standard BioTools) coupled to a CyTOF First Generation mass cytometer

(18) Spatiotemporal organisation of residual disease in mouse and human BRCA1-deficient mammary tumours and breast cancerNature CommunicationsJune 11, 2026Demeter Túrós, Morgane Decollogny, Anna Moyseos, Astrid Chanfon, Myriam Siffert, Joanne Bousmar, Lou Romanens, Jean-Christophe Tille, Olivier Tredan, Intidhar Labidi-Galy, et al.quickly rinsed in distilled water and air-dried prior to acquisition. IMC data were acquired using the Hyperion™ Tissue Imager (Standard BioTools). Tissue was ablated using a 1 μm-diameter UV laser operating at 200

(19) Modeling immune responses to autologous and allogeneic human stem cell–derived islet grafts in vivoJCI InsightJune 8, 2026Camillo Bechi Genzano, Giorgia Zanetti, Qian Du, Daniel Traum, Deeksha Lahori, Grant M. Downes, Sakshi A. Bhatele, Xiaolan Ding, Kyle D. Apley, Rebuma Firdessa Fite, et al.twice in ultrapure 18.2 MΩ water, before being air dried and acquired on the IMC (Standard BioTools, Hyperion Imaging System) according to Standard BioTools’ standard operating procedures, with a 200 Hz laser frequency and a

(20) Mapping Immunity With Cutting‐Edge Spatial Biology and Tissue Cytometry InnovationsMedComm (2020)June 1, 2026Lilibeth Cárdenas‐Piedra, Selwin G. Samuel, Felicitas Mungenast, Dinesh Yasothkumar, Rupert C. Ecker, Jyotsna Batraauto‐configuration after dye selection Up to 9‐plex in a single round,Manual sample preprocessing and staining,[44] Hyperion XTi imaging System/ Standard Biotools,RNA: FISH/ RNAscope (RNAscope HiPlex V2) Protein: mass‐tagged

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