Bioassay Technology Laboratory's HDAC4 Monoclonal Antibody is a Mouse monoclonal antibody. It reacts with Human, Mouse, Rat, Canine, Chicken/Bird, Drosophila/Arthropod, Hamster, Non-Human Primate, Porcine, Rabbit, Sheep, and Yeast/Fungi.
Description
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3