Fig 1: Plasma EV protein biomarkers for the diagnosis of LUSC. (A) Proteins with the highest predictive values in classifying LUSC and BLD with XGBoost. (B) ROC curve and confusion matrix in the training set. (C) ROC curve and confusion matrix in the test set. (D) ROC curve and confusion matrix in the entire cohort. SEN (Sensitivity) and SPE (Specificity) refer to diagnostic performance metrics for distinguishing LUSC from BLD samples. (E) Levels of TUBB3 in total plasma from patients with LUSC and BLD. A total of 74 samples (38 BLD and 36 LUSC) were tested. (F) Levels of RPS7 in total plasma from patients with LUSC and BLD. A total of 149 samples (44 BLD and 105 LUSC) were tested