Fig 1: Effects of atorvastatin on expression and enzymatic activity of various proteins in the liver of adenine-induced CKD rats. (a) HMG-CoA reductase (HMGCR), (b) ACAT2, (c) LDL receptor (LDLr), (d) LCAT, and (e) SR-B1 protein expression as determined by western blot analysis in liver of rats treated for 24 days either with normal diet (control) or adenine-supplemented diet (CKD) alone or with atorvastatin (CKD + ATV). Enzyme activity of (f) HMG-CoA reductase, (g) ACAT2, and (h) LCAT in the liver of control, CKD, and atorvastatin-treated rats. Relative optical density was calculated relative to β-actin used as internal control. Each bar represents the mean ± SEM of 5–6 rats calculated. Significant difference from control: #p < 0.05, ##p < 0.01, and ###p < 0.001. Significant difference from CKD: ∗p < 0.05 and ∗∗p < 0.01.