Fig 1: Level of bacteriuria and inflammatory biomarkers during infection of pigs (n = 4). The infected pig bladders remain significantly colonized throughout the experiment (A). Within the first 24 h of infection, granulocytes are rapidly rising reaching maximum concentrations of 14.9 × 109/ml. Shortly after, a small drop in granulocyte level is observed though remaining elevated until termination of the experiment (B). CRP increases > 7-fold at 24 hpi (peak-value) and decrease linearly hereafter, reaching baseline values at 7 dpi (C). No observable change in levels of IL-6 was seen during infection (D). Graphs represent means ± standard error of the mean. ∗P < 0.05, ∗∗P < 0.001, one-way ANOVA with Tukey’s multiple comparisons test. Data from 7 days onward are based on two pigs only. CFU, colony forming units; IL-6, interleukin-6.
Fig 2: CRP concentration in CSF of the pigs receiving NaCl (control group, black bars), pigs receiving ASC (white bars), pigs receiving WJ-MSC (grey bars) in a four timepoints of the experiment: 0: pre-1st cells/NaCl administration, I: post-1st cells/NaCl administration, II: post-2st cells/NaCl administration, III: CRP decreased after the second administration of NaCl, while in the ASC group itremained at the same level one week after NTs administration (III). Data are presented as mean ± SD (n = 3 per group). Due to the small sample size, individual data points are not displayed. The statistical analysis was determined by a two-way ANOVA followed by Tukey’smultiple comparison test (p < 0.05). Asterisks indicate differences in the CRP concentration between examining timepoints (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001).
Fig 3: CRP concentration in plasma of the pigs receiving NaCl (control group, black bars), pigs receiving ASC (white bars), pigs receiving WJ-MSC (grey bars) in a four timepoints of the experiment: O: pre-1st cells/NaCl administration, I: post-1st cells/NaCl administration, II: post-2st cells/NaCl administration, III: one week after NTs administration. Data are presented as mean ± SD (n = 3 per group). Due to the small sample size, individual data points are not displayed. The statistical analysis was determined by a two-way ANOVA followed by Tukey’smultiple comparison test (p < 0.05). Asterisks indicate differences in the CRP concentration between examining timepoints (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001).
Supplier Page from Abcam for Pig CRP ELISA Kit