Fig 1: a) Correlation graph of ß-Cell response vs Akt2, IRS 1, and PI3K b) mean hepatic Akt2 levels c) mean hepatic IRS 1 levels d) mean hepatic PI3K levels. **- no significant changes relative to normoglycemic rats, #-significantly higher than the control but lower than the negative control (DU), *-no significant difference with the normoglycemic rats