Fig 1: ANGPTL4 expression in different cybrids under hypoxia-ischemia and the relationship with HIF-1α. Comparison of the knockdown effect of HIF-1α siRNA on expressions of HIF-1α and ANGPTL4 in cybrid cells harboring stroke-susceptible haplogroup F and resistant haplogroup B. Baseline expression of HIF-1α (A) and ANGPTL4 (C) and effects of HIF-1α siRNA on expressions of HIF-1α (B) and ANGPTL4 (D) before and after hypoxia-ischemia, as assessed by Western blot analysis. Actin was used as a loading control. Data represent the mean ±SD of at least three independent experiments (* p < 0.05; # p < 0.005). N was used to represent normoxic and H to represent the hypoxic condition.