Description
Alpha-2-macroglobulin (A2M) is a major serum protein with diverse functions, including inhibition of protease activity and binding of growth factors, cytokines, and disease factors (1). Increased alpha-2-macroglobulin in serum has been suggested to be associated with multiple sclerosis (MS) (2), glomerular disease (3), and liver diseases (4). Mouse alpha-2-macroglobulin is believed to be a functional homologue of human alpha-2-macroglobulin