Fig 1: Study plan as regards assessment of biomarker prognostic value in moderate–severe traumatic brain injury. In this observational analytic study encompassing the prospective cohort and cross-sectional sub-studies, controls and patients diagnosed of moderate–severe traumatic brain injury were recruited, so as to observe alteration of serum-based transcription levels and its prognostic value following head trauma. GCS = Glasgow coma scale, msTBI = moderate–severe traumatic brain injury, TFEB = transcription factor EB.
Fig 2: Nomogram visually assessing prognosis model in moderate–severe traumatic brain injury. The independent predictors of poor prognosis, that is, serum transcription factor levels, Glasgow coma scale scores, and Rotterdam computerized tomography scores, were consolidated to build the model for predicting poor prognosis. The model was pictorially represented by the nomogram. CT = computerized tomography, GCS = Glasgow coma scale, TFEB = transcription factor EB.
Fig 3: Linearity connection of serum-based transcription factor EB levels with poor prognosis risk after moderate–severe traumatic brain injury. Based on the scenario of the restricted cubic spline, serum-based transcription factor EB levels had linear correlation with poor prognosis likelihood after moderate–severe traumatic brain injury (P for nonlinear > .05). TFEB = transcription factor EB.
Fig 4: Exhibition of prognosis prediction ability of combined model in moderate–severe traumatic brain injury. Model 1 was composed of serum transcription factor EB levels, Glasgow coma scale scores, and Rotterdam computerized tomography scores. Model 2 comprised Glasgow coma scale scores and Rotterdam computerized tomography scores. In terms of prognosis anticipation, model 1 displayed substantially highest ability among 5 assessment approaches under the receiver operating characteristic curve (*P < .05, *P < .01). AUC = area under curve, 95% CI = 95% confidence interval, CT = computed tomography, GCS = Glasgow coma scale, TFEB = transcription factor EB.
Fig 5: Validity assessment of prognosis model in moderate–severe traumatic brain injury. Model 1 encompassed serum transcription factor EB levels, Glasgow coma scale scores, and Rotterdam computerized tomography scores. Model 2 included Glasgow coma scale scores and Rotterdam computerized tomography scores. In terms of prognosis validity, model 1 displayed significantly highest levels among 5 indicators under the decision curve. CT = computed tomography, GCS = Glasgow coma scale, TFEB = transcription factor EB.
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