Fig 1: Lpar2 deficiency increases the mortality, pulmonary damage and inflammation in LPS-induced mice. (A) Survival of WT and Lpar2−/− mice challenged with LPS (n = 24). (B) Representative images of the lung tissue in WT and Lpar2−/− mice. (C-1) Representative images of HE-stained lung tissue. Red arrows indicate inflammatory cell infiltration, black arrows indicate thickening of the alveolar walls. Scale bar, 100 μm. (C-2) The lung injury area was quantified by assessing the histological scores for each treatment group (n = 6). (D) Total neutrophil levels in the BALF (n = 6). (E1–3) CXCL15, TNF-α and IL-6 levels in the BALF (n = 6), *p < 0.05 and **p < 0.01 vs the LPS-WT group.