Fig 1: Effects of yeast extract on wrinkle-related protein expression in HDF. Collagen-1 (A) and elastin (B) protein levels were significantly reduced after UVB irradiation, and yeast extract reversed this effect. On the other hand, UVB exposure enhanced the protein expression of MMP-1 (C), MMP-3 (D), and MMP-9 (E), but yeast extract successfully countered these influences. MMP, matrix metalloproteinase; RA, Retinoic acid, 1 µM; UVB, ultraviolet B. ****p < 0.001, independent samples t-test compared to non-irradiated control group; ###p < 0.005, ####p < 0.001, independent samples t-test compared to UVB-irradiated control group