Description
In mice, Multimerin-2 (MMRN2) primarily contributes to angiogenesis, inhibits tumor growth, and ensures vascular stability. These roles are facilitated through several mechanisms, such as interacting with vascular endothelial cells and pericytes, modulating angiogenesis-related signaling pathways, and maintaining the integrity of vascular structures. In various disease models, alterations in MMRN2 expression are linked to numerous pathological conditions. Specifically, in retinopathy, there is a notable increase in the binding of MMRN2 to CD93, which is identified as a crucial factor in promoting retinal neovascularization. This implies that MMRN2 is significantly involved in disease-associated angiogenesis