Description
TAPS+ is a positive-readout methylation sequencing chemistry that converts methylated C’s (5mC’s) to T’s while preserving unmethylated C’s. Unlike traditional methyl-seq approaches, it maintains full base complexity (ATCG) without damaging DNA, enabling high-quality performance with low-input and degraded samples. This unified approach delivers 5mC, SNV/indel, and CNV detection from a single library for multimodal analysis across discovery, translational, and population studies to support field innovations in applications such as early disease detection and monitoring.
- Direct 5mC readout enables simultaneous detection of genetic variants (SNV/Indels and CNVs) and epigenetic modifications from the same library
- Greater than 98% 5mC conversion — including both hypo
- and hyper-methylated regions — delivers high true positive and low false positive rates
- Higher sequence diversity boosts mappability, reduces multi-mapping / low-complexity dropouts, and lifts CpG coverage at a given read depth
- Nondamaging workflow delivers robust performance with degraded FFPE and low-input samples (down to 1 ng), including cfDNA
- Streamlined, automation-friendly workflow generates libraries in 6 hours — no columns required
- Reduce computational analysis time by 30% or more, saving hours and associated costs on a 30X genome.