Description
C5a is a protein fragment generated when complement component C5 is cleaved by the protease C5-convertase, resulting in the formation of C5a and C5b fragments. C5a functions as a potent inflammatory peptide, promoting complement activation, formation of the membrane attack complex (MAC), recruitment of innate immune cells, and the release of histamine, which is involved in allergic responses. C5a plays a key role in the inflammatory response. For example, in a rabbit lung inflammation model, C5a was able to cause neutrophil aggregation and alveolar damage