Description
CTGF, also known as CCN2 or connective tissue growth factor, is a matricellular protein that belongs to the CCN family of extracellular matrix-associated heparin-binding proteins. Members of the CCN protein family, including CTGF, are structurally defined by four conserved, cysteine-rich domains. In rabbits, this protein is encoded by the CCN2 gene. CTGF has been shown to be strongly associated with tissue repair and fibrosis in a variety of rabbit models. For example, CTGF expression was significantly increased during corneal wound healing, and its inhibition reduced scar formation