Description
Amyloid-beta precursor protein acts as a cell surface receptor with essential physiological roles on the surface of neurons, including promoting neurite growth, neuronal adhesion, and axonogenesis. The interaction between APP molecules on adjacent cells facilitates synaptogenesis. It also plays a role in cell mobility and transcription regulation via protein-protein interactions. APP can enhance transcription activation by binding to APBB1-KAT5 and inhibit Notch signaling through its interaction with Numb. Functional studies in mice have demonstrated APP's significant involvement in Alzheimer's disease pathogenesis, encompassing Aβ generation, toxic aggregation, neuronal dysfunction, and neuroprotection