Description
In rabbits, Interleukin 5 is encoded by the IL5 gene. The IL-5 gene in rabbits is located on chromosome 5 and is co-regulated with other Th2 cytokines, such as IL-4 and IL-13. This homodimeric cytokine is primarily expressed by T-lymphocytes and NK cells and plays a crucial role in the survival, differentiation, and chemotaxis of eosinophils. Additionally, it influences activated and resting B-cells by inducing immunoglobulin production, growth, and differentiation. Mechanistically, it achieves its biological effects via a receptor comprised of the IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB