Description
Complement factor D cleaves factor B when it is complexed with factor C3b, leading to the activation of the C3bBb complex, which becomes the C3 convertase of the alternative pathway. Its function is similar to that of C1s in the classical pathway. In mice, complement factor D plays a crucial role in activating the alternative pathway, regulating inflammation and immune responses, and aiding tissue repair. CFD is involved in both the classical and alternative pathways of the complement system by catalyzing the cleavage of C3 to produce C3b, and it demonstrates either protective or pathological effects across various disease models